| Mechanisms of injury in hypoxic-ischemic encephalopathy: implications to therapy. | |
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MedLine Citation:
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PMID: 16969737 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cardiac arrest survivors commonly suffer ischemic brain injury, and understanding the mechanisms of injury is essential to providing insight for effective therapies for brain protection. Injury can occur at the time of the cardiac arrest and is dependent not only on the duration but also the degree of impaired circulation. Injury can be ongoing even after the return of spontaneous circulation, giving the clinician an additional window of opportunity to treat and protect the injured brain. This section will review the molecular basis of injury with cardiac arrest and will elucidate the different mechanisms of injury between cardiac arrest, pure respiratory arrest, and arrest secondary to toxins (e.g., carbon monoxide). The rationale for multiple postarrest therapies, such as hypothermia and induced hypertension, will also be reviewed. |
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Authors:
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David M Greer |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Seminars in neurology Volume: 26 ISSN: 0271-8235 ISO Abbreviation: Semin Neurol Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-09-13 Completed Date: 2006-11-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8111343 Medline TA: Semin Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 373-9 Citation Subset: IM |
Affiliation:
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Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / blood supply*, metabolism, physiopathology* Carbon Monoxide Poisoning / complications, physiopathology Heart Arrest / complications* Humans Hypothermia, Induced / trends Hypoxia-Ischemia, Brain / etiology*, physiopathology*, therapy Neuroprotective Agents / therapeutic use Respiratory Insufficiency / complications Thrombolytic Therapy / trends Vasoconstrictor Agents / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Neuroprotective Agents; 0/Vasoconstrictor Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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