| Mechanisms for inhibition of free fatty acid mobilization by nicotinic acid and sodium salicylate in canine subcutaneous adipose tissue in situ. | |
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MedLine Citation:
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PMID: 663543 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mechanisms for reduced free fatty acids (FFA) mobilization effected by nicotinic acid (NA) and sodium salicylate (SS) were studied in canine adipose tissue in situ. Both drugs inhibited adipose tissue lipolysis as evidenced by reduced release of glycerol. In addition, although the total amount of FFA re-esterified was not significantly changed, the amount of FFA re-esterified relative to the amount of FFA liberated intracellularly was significantly increased by both drugs. These effects were most pronounced during isoprenaline-stimulated lipolysis. Thus NA and SS reduced mobilization of FFA from canine adipose tissue through a combined effect on re-esterification and lipolysis. |
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Authors:
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H Vik-Mo; O D Mjøs |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Scandinavian journal of clinical and laboratory investigation Volume: 38 ISSN: 0036-5513 ISO Abbreviation: Scand. J. Clin. Lab. Invest. Publication Date: 1978 May |
Date Detail:
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Created Date: 1978-08-14 Completed Date: 1978-08-14 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0404375 Medline TA: Scand J Clin Lab Invest Country: NORWAY |
Other Details:
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Languages: eng Pagination: 209-16 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
/
blood supply,
metabolism* Animals Dogs Fatty Acids, Nonesterified / metabolism* Female Glucose / metabolism Hemodynamics / drug effects Isoproterenol / pharmacology Lipid Metabolism Male Nicotinic Acids / pharmacology* Sodium Salicylate / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Nonesterified; 0/Nicotinic Acids; 50-99-7/Glucose; 54-21-7/Sodium Salicylate; 7683-59-2/Isoproterenol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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