Document Detail


Mechanisms for inhibition of free fatty acid mobilization by nicotinic acid and sodium salicylate in canine subcutaneous adipose tissue in situ.
MedLine Citation:
PMID:  663543     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mechanisms for reduced free fatty acids (FFA) mobilization effected by nicotinic acid (NA) and sodium salicylate (SS) were studied in canine adipose tissue in situ. Both drugs inhibited adipose tissue lipolysis as evidenced by reduced release of glycerol. In addition, although the total amount of FFA re-esterified was not significantly changed, the amount of FFA re-esterified relative to the amount of FFA liberated intracellularly was significantly increased by both drugs. These effects were most pronounced during isoprenaline-stimulated lipolysis. Thus NA and SS reduced mobilization of FFA from canine adipose tissue through a combined effect on re-esterification and lipolysis.
Authors:
H Vik-Mo; O D Mjøs
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of clinical and laboratory investigation     Volume:  38     ISSN:  0036-5513     ISO Abbreviation:  Scand. J. Clin. Lab. Invest.     Publication Date:  1978 May 
Date Detail:
Created Date:  1978-08-14     Completed Date:  1978-08-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0404375     Medline TA:  Scand J Clin Lab Invest     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  209-16     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / blood supply,  metabolism*
Animals
Dogs
Fatty Acids, Nonesterified / metabolism*
Female
Glucose / metabolism
Hemodynamics / drug effects
Isoproterenol / pharmacology
Lipid Metabolism
Male
Nicotinic Acids / pharmacology*
Sodium Salicylate / pharmacology*
Chemical
Reg. No./Substance:
0/Fatty Acids, Nonesterified; 0/Nicotinic Acids; 50-99-7/Glucose; 54-21-7/Sodium Salicylate; 7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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