| Mechanisms of increased vascular superoxide production in human varicose veins. | |
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MedLine Citation:
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PMID: 21860369 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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INTRODUCTION: Varicose vein disease is one of the most common morbidities in developed countries. Recent studies have shown that oxidative stress is increased in varicose veins (VV) and venous insufficiency. However, the exact mechanisms of oxidative stress in VV remain unknown. OBJECTIVES: We aimed to measure superoxide anion production and analyze it's enzymatic sources in varicose veins in comparison to control human saphenous veins (HSV). Superoxide production was also compared between distal and proximal segments of veins. PATIENTS AND METHODS: Distal and proximal segments of varicose (n=14 patients, aged 52±3.5 years) and control veins (n=15 patients, aged 56±4 years) were obtained during varicose vein removal or elective coronary artery bypass graft surgery respectively. Subjects were matched for age, sex, and major risk factors for atherosclerosis. Superoxide was measured by lucigenin enhanced chemiluminescence (5 mol/l) in the presence and absence of oxidase inhibitors. RESULTS: Superoxide production was increased in VV, compared to control HSV. This increase was particularly evident in distal segments of varicose vessels. There was a significant correlation between superoxide production in distal and proximal segments of HSV but not of VV. NADPH oxidases and uncoupled nitric oxide synthase (NOS) were the major sources of superoxide in VV, as their inhibitors greatly attenuated superoxide production in VV. CONCLUSIONS: NADPH oxidases and NOS could represent valuable drug targets for pharmacological treatment and prevention of varicose venous disease. Oxidative stress may provide a link between endothelial dysfunction, inflammation and immune activation and the development of chronic venous dysfunction. |
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Authors:
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Bartłomiej Guzik; Maciej Chwala; Paweł Matusik; Dominik Ludew; Dominik Skiba; Grzegorz Wilk; Wojciech Mrowiecki; Bogdan Batko; Andrzej Cencora; Bogusław Kapelak; Jerzy Sadowski; Ryszard Korbut; Tomasz J Guzik |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-22 |
Journal Detail:
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Title: Polskie Archiwum Medycyny Wewnetrznej Volume: - ISSN: 1897-9483 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401225 Medline TA: Pol Arch Med Wewn Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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