| Mechanism(s) of in utero meconium passage. | |
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MedLine Citation:
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PMID: 19057616 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To use sheep and rat models and demonstrate that stressors activate fetal glucocorticoid (GC) system, corticotrophin-releasing factor (CRF) system and cholinergic neurotransmitter system (ChNS) leading to propulsive colonic motility and in utero meconium passage. Immunohistochemical studies (IHS) were performed to localize GC-Receptors, CRF-receptors and key molecules of ChNS in sheep fetal distal colon. CRF expression in placenta and enteric endocrine cells in fetal rat system were examined and the effects of acute hypoxia on in utero meconium passage was tested. IHS confirmed localization and gestation dependent changes in GC-Rs, CRF-Rs and cholinergic markers in sheep fetal colon. Rat placenta and enteric endocrine cells express CRF and gastrointestinal tract express CRF-Rs. Hypoxia is a potent inducer of meconium passage in term fetal rats. Stress is a risk factor for in utero meconium passage and laboratory animal models can be used to develop pharmacotherapy to prevent stress-induced in utero meconium passage. |
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Authors:
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J Lakshmanan; M G Ross |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Journal of perinatology : official journal of the California Perinatal Association Volume: 28 Suppl 3 ISSN: 1476-5543 ISO Abbreviation: J Perinatol Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-12-05 Completed Date: 2009-04-23 Revised Date: 2010-06-07 |
Medline Journal Info:
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Nlm Unique ID: 8501884 Medline TA: J Perinatol Country: United States |
Other Details:
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Languages: eng Pagination: S8-13 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Harbor-UCLA Medical Center, Torrance, CA 90502, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenocorticotropic Hormone
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physiology Animals Anoxia / complications* Disease Models, Animal Gastrointestinal Motility* Glucocorticoids / physiology Humans Meconium / physiology* Rats Risk Factors Sheep Stress, Physiological* |
| Grant Support | |
ID/Acronym/Agency:
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R03 HD051574-01A1/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 9002-60-2/Adrenocorticotropic Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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