Document Detail

Mechanism(s) of in utero meconium passage.
MedLine Citation:
PMID:  19057616     Owner:  NLM     Status:  MEDLINE    
To use sheep and rat models and demonstrate that stressors activate fetal glucocorticoid (GC) system, corticotrophin-releasing factor (CRF) system and cholinergic neurotransmitter system (ChNS) leading to propulsive colonic motility and in utero meconium passage. Immunohistochemical studies (IHS) were performed to localize GC-Receptors, CRF-receptors and key molecules of ChNS in sheep fetal distal colon. CRF expression in placenta and enteric endocrine cells in fetal rat system were examined and the effects of acute hypoxia on in utero meconium passage was tested. IHS confirmed localization and gestation dependent changes in GC-Rs, CRF-Rs and cholinergic markers in sheep fetal colon. Rat placenta and enteric endocrine cells express CRF and gastrointestinal tract express CRF-Rs. Hypoxia is a potent inducer of meconium passage in term fetal rats. Stress is a risk factor for in utero meconium passage and laboratory animal models can be used to develop pharmacotherapy to prevent stress-induced in utero meconium passage.
J Lakshmanan; M G Ross
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  28 Suppl 3     ISSN:  1476-5543     ISO Abbreviation:  J Perinatol     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-05     Completed Date:  2009-04-23     Revised Date:  2010-06-07    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S8-13     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
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MeSH Terms
Adrenocorticotropic Hormone / physiology
Anoxia / complications*
Disease Models, Animal
Gastrointestinal Motility*
Glucocorticoids / physiology
Meconium / physiology*
Risk Factors
Stress, Physiological*
Grant Support
R03 HD051574-01A1/HD/NICHD NIH HHS
Reg. No./Substance:
0/Glucocorticoids; 9002-60-2/Adrenocorticotropic Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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