Document Detail

Mechanisms in man for rapid refill of the circulatory system in hypovolaemia.
MedLine Citation:
PMID:  1481686     Owner:  NLM     Status:  MEDLINE    
Compensatory, net fluid transfer across the capillaries was studied in the arm of man with plethysmographic technique during experimental hypovolaemia induced by lower body negative pressure (LBNP). Thirty, 60, and 110 cmH2O LBNP evoked rapid transfer of fluid from tissue to blood at average rates of 0.053, 0.088 and 0.147 ml min-1 100 ml-1 soft tissue, i.e. graded responses typical for a true homeostatic regulation. Other experiments demonstrated a net fluid absorption not only from the arm but also from a wide range of skeletal muscle and skin regions in the body during experimental hypovolaemia, i.e. the more or less generalized response required if the absorption process is to contribute importantly to plasma volume regulation. In a third series of experiments it was shown that gradually applied LBNP was a much less efficient stimulus for fluid gain into the circulation than rapidly instituted LBNP, tentatively explaining the fairly slow plasma volume refill in main in previous literature after experimental, true and necessarily slow blood loss. Taken together, the findings described warrant the conclusion that the described process of fluid gain into the circulation may be a very important component in the overall homeostatic circulatory regulation in states of hypovolaemia. The data in fact suggest that the process might be capable of increasing plasma volume by as much as 600 ml within only 10 min, suggesting that such plasma volume control might be much more potent than previously believed.
T Länne; J Lundvall
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta physiologica Scandinavica     Volume:  146     ISSN:  0001-6772     ISO Abbreviation:  Acta Physiol. Scand.     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1993-02-09     Completed Date:  1993-02-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370362     Medline TA:  Acta Physiol Scand     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  299-306     Citation Subset:  IM; S    
Department of Clinical Physiology, Malmõ General Hospital, Sweden.
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MeSH Terms
Blood Volume / physiology*
Capillaries / physiology
Forearm / blood supply
Hemodynamics / physiology*
Leg / blood supply
Lower Body Negative Pressure*
Muscles / blood supply
Regional Blood Flow / physiology
Skin / blood supply

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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