Document Detail

Mechanisms in anti-inflammation and resolution: the role of lipoxins and aspirin-triggered lipoxins.
MedLine Citation:
PMID:  11323741     Owner:  NLM     Status:  MEDLINE    
Multicellular host responses to infection, injury or inflammatory stimuli lead to the formation of a broad range of chemical mediators by the host. The integrated response of the host is essential to health and disease; thus it is important to achieve a more complete understanding of the molecular and cellular events governing the formation and actions of endogenous mediators of resolution that appear to control the duration of inflammation. Lipoxins are trihydroxytetraene-containing lipid mediators that can be formed during cell-cell interactions and are predominantly counterregulators of some well-known mediators of inflammation. Since this circuit of lipoxin formation and action appears to be of physiological relevance for the resolution of inflammation, therapeutic modalities targeted at this system are likely to have fewer unwanted side effects than other candidates and current anti-inflammatory therapies. Here, we present an overview of the recent knowledge about the biosynthesis and bioactions of these anti-inflammatory lipid mediators.
I M Fierro; C N Serhan
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.]     Volume:  34     ISSN:  0100-879X     ISO Abbreviation:  Braz. J. Med. Biol. Res.     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-04-27     Completed Date:  2001-08-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8112917     Medline TA:  Braz J Med Biol Res     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  555-66     Citation Subset:  IM    
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
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MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
Aspirin / pharmacology*
Autacoids / biosynthesis
Cytokines / physiology
Hydroxyeicosatetraenoic Acids / biosynthesis,  immunology,  physiology*
Inflammation / drug therapy*,  metabolism,  physiopathology
Inflammation Mediators / metabolism,  physiology*
Lipids / biosynthesis*
Lipoxygenase / biosynthesis
Grant Support
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Autacoids; 0/Cytokines; 0/Hydroxyeicosatetraenoic Acids; 0/Inflammation Mediators; 0/Lipids; 0/Lipoxins; 0/lipoxin A4; 50-78-2/Aspirin; EC

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