Document Detail

Mechanisms in adverse reactions to food. The eye.
MedLine Citation:
PMID:  7741209     Owner:  NLM     Status:  MEDLINE    
Direct action of triggers on the target organ may cause vasodilation, exudation, hypersecretion and nerve endings stimulation without participation of mast cells and basophils. Non IgE-mediated release of mediators from mast cells and basophils may explain how triggers other than allergens can induce pseudo-allergic reactions. IgE-mediated triggering of mast cells and basophils is not confined - in the eye too - to an immediate reaction, but represents the starting point for a progression to a late-phase reaction with the participation of a network of several cells and mediators. Inflammatory changes associated with late-phase reaction in the eye represent the pathophysiological basis for a non-specific hyperreactivity to various triggers.
S Bonini; S Bonini
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Allergy     Volume:  50     ISSN:  0105-4538     ISO Abbreviation:  Allergy     Publication Date:  1995  
Date Detail:
Created Date:  1995-06-07     Completed Date:  1995-06-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7804028     Medline TA:  Allergy     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  68-73     Citation Subset:  IM    
Chair of Clinical Immunology and Allergy, Second University of Naples, Instituto di I Clinica Medica, Policlinico Umberto, Rome, Italy.
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MeSH Terms
Conjunctivitis, Allergic / diagnosis,  etiology*,  physiopathology
Eye / physiopathology
Food Hypersensitivity / complications*,  immunology,  physiopathology
Immunoglobulin E / metabolism
Reg. No./Substance:
37341-29-0/Immunoglobulin E

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