Document Detail


Mechanisms of implantation: strategies for successful pregnancy.
MedLine Citation:
PMID:  23223073     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Physiological and molecular processes initiated during implantation for pregnancy success are complex but highly organized. This review primarily highlights adverse ripple effects arising from defects during the peri-implantation period that perpetuate throughout pregnancy. These defects are reflected in aberrations in embryo spacing, decidualization, placentation and intrauterine embryonic growth, manifesting in preeclampsia, miscarriages and/or preterm birth. Understanding molecular signaling networks that coordinate strategies for successful implantation and decidualization may lead to approaches to improve the outcome of natural pregnancy and pregnancy conceived from in vitro fertilization.
Authors:
Jeeyeon Cha; Xiaofei Sun; Sudhansu K Dey
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Nature medicine     Volume:  18     ISSN:  1546-170X     ISO Abbreviation:  Nat. Med.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-11     Completed Date:  2013-02-11     Revised Date:  2014-05-12    
Medline Journal Info:
Nlm Unique ID:  9502015     Medline TA:  Nat Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1754-67     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Decidua / physiology*
Embryo Implantation / physiology*
Female
Humans
Mice
Models, Biological*
Placentation / physiology*
Pregnancy
Pregnancy Complications / physiopathology*
Pregnancy Outcome
Signal Transduction / physiology*
Uterus / physiology*
Grant Support
ID/Acronym/Agency:
DA06668/DA/NIDA NIH HHS; F30 AG040858/AG/NIA NIH HHS; F30AG040858/AG/NIA NIH HHS; HD068524/HD/NICHD NIH HHS; HD12304/HD/NICHD NIH HHS; R01 HD068524/HD/NICHD NIH HHS; R37 DA006668/DA/NIDA NIH HHS; R37 HD012304/HD/NICHD NIH HHS; T32 GM063483/GM/NIGMS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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