Document Detail

Mechanisms of impaired renal function with PEEP.
MedLine Citation:
PMID:  6379297     Owner:  NLM     Status:  MEDLINE    
Deterioration in renal function associated with positive end-expiratory pressure (PEEP) has been attributed to renal hypoperfusion from the fall in cardiac output and mean arterial blood pressure. Using a canine in vivo model, renal function was measured during control, zero end-expiratory pressure (ZEEP), and PEEP (5, 10, and 15 cm H2O) ventilatory cycles, while renal blood flow was maintained constant with a pump. High PEEP (15 cm H2O) led to a rise in renal vein pressure (RVP) and a fall in mean arterial pressure (MAP). PEEP resulted in no change in glomerular filtration rate (GFR) or solute exertion; however, free-water clearance (FWC) became less negative in the 15-cm H2O PEEP group. Intrarenal autoregulation maintains GFR during ventilation with PEEP when renal blood flow is constant, supporting the view that altered filtration and solute excretion clinically is secondary to changes in aortic pressure and renal perfusion.
R J Mullins; E J Dawe; C E Lucas; A M Ledgerwood; S M Banks
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of surgical research     Volume:  37     ISSN:  0022-4804     ISO Abbreviation:  J. Surg. Res.     Publication Date:  1984 Sep 
Date Detail:
Created Date:  1984-09-19     Completed Date:  1984-09-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376340     Medline TA:  J Surg Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  189-96     Citation Subset:  IM    
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MeSH Terms
Aorta / physiology
Blood Pressure
Cardiac Output
Glomerular Filtration Rate
Kidney / physiopathology*
Positive-Pressure Respiration*
Pulmonary Artery / physiology
Renal Circulation*
Renal Veins / physiology
Grant Support

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