Document Detail

Mechanisms of impaired cardiac function by vasopressin.
MedLine Citation:
PMID:  7369815     Owner:  NLM     Status:  MEDLINE    
The mechanisms by which elevated levels of vasopressin (ADH) in man and animals cause serious myocardial dysfunction, evidenced by arrhythmias, reduction in cardiac output and coronary blood flow, are not settled. Experiments were conducted in 16 isolated working left ventricles to examine their metabolic and hemodynamic responses to the infusion of vasopressin and the combination of vasopressin and epinephrine. Contractile performance was evaluated by analysis of positive dP/dt, contractile element velocities, and ventricular work-curves using stroke work/end-diastolic pressure. Relaxation parameters, including negative dP/dt and the early diastolic relaxation time constant, were also studied. Coronary blood flow was reduced 22% or less by vasopressin while cardiac output was maintained at a constant level. Myocardial oxygen consumption, lactate and potassium balances were determined from arterial and coronary sinus concentrations. Vasopressin produced myocardial dysfunction indicated by decrements in contractile and relaxation indices, without evidence of global ischemia. Epinephrine restored the mechanical performance to normal without significant change in coronary blood flow, myocardial oxygen consumption, or lactate and potassium balance.
M F Wilson; D J Brackett; L T Archer; L B Hinshaw
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Annals of surgery     Volume:  191     ISSN:  0003-4932     ISO Abbreviation:  Ann. Surg.     Publication Date:  1980 Apr 
Date Detail:
Created Date:  1980-06-16     Completed Date:  1980-06-16     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372354     Medline TA:  Ann Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  494-500     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Pressure / drug effects
Cardiac Output / drug effects
Coronary Circulation / drug effects
Epinephrine / pharmacology
Heart / physiology*
Heart Rate / drug effects
Lactates / blood
Myocardial Contraction / drug effects
Myocardium / metabolism
Oxygen / blood
Oxygen Consumption / drug effects
Potassium / blood
Stroke Volume / drug effects
Vasopressins / pharmacology*
Ventricular Function
Reg. No./Substance:
0/Lactates; 11000-17-2/Vasopressins; 51-43-4/Epinephrine; 7440-09-7/Potassium; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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