Document Detail

Mechanisms of immune tolerance relevant to food allergy.
MedLine Citation:
PMID:  21277624     Owner:  NLM     Status:  MEDLINE    
The intestine has an unenviable task: to identify and respond to a constant barrage of environmental stimuli that can be both dangerous and beneficial. The proper execution of this task is central to the homeostasis of the host, and as a result, the gastrointestinal tract contains more lymphocytes than any other tissue compartment in the body, as well as unique antigen-presenting cells with specialized functions. When antigen is initially encountered through the gut, this system generates a robust T cell-mediated hyporesponsiveness called oral tolerance. Although seminal observations of oral tolerance were made a century ago, the relevant mechanisms are only beginning to be unraveled with the use of modern investigational techniques. Food allergy is among the clinical disorders that occur from a failure of this system, and therapies that seek to re-establish tolerance are currently under investigation.
Brian P Vickery; Amy M Scurlock; Stacie M Jones; A Wesley Burks
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-01-31
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  127     ISSN:  1097-6825     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-07     Completed Date:  2011-05-25     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  576-84; quiz 585-6     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2011 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.
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MeSH Terms
Administration, Oral
Food Hypersensitivity / immunology*
Gastrointestinal Tract* / immunology
Immune Tolerance*
Intestinal Mucosa / immunology
T-Lymphocytes / immunology
Grant Support
1 R01-AI06874-01A1/AI/NIAID NIH HHS; 1 UL1 RR024128-01/RR/NCRR NIH HHS; K08 AI077932/AI/NIAID NIH HHS; R01 AI068074/AI/NIAID NIH HHS; R01 AI068074-05/AI/NIAID NIH HHS; R01 AT004435/AT/NCCAM NIH HHS; R01 AT004435-05/AT/NCCAM NIH HHS; R21 AT002557/AT/NCCAM NIH HHS; R21 AT002557-03/AT/NCCAM NIH HHS

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