Document Detail

Mechanisms of immune-mediated skin diseases: an overview.
MedLine Citation:
PMID:  16466619     Owner:  NLM     Status:  MEDLINE    
The skin is a frequent site of pathological immune responses that can take place in the dermal and/or the epidermal compartments.These immunopathological reactions often occur towards innocuous antigens and may be the result of T cell-dependent and/or autoantibody dependent mechanisms. Defective immune regulation is increasingly recognized as very relevant in many skin and systemic immune-mediated disorders. In some instances (e.g., psoriasis and atopic dermatitis) genetic predisposition can affect also the capacity of keratinocytes to initiate or perpetuate inflammatory responses. A more precise understanding of the molecular and cellular mechanisms underlying each disorder may allow the identification of novel targets for more effective therapeutic strategies.
S Beissert; I Cavazzana; F Mascia; P Meroni; S Pastore; G Tessari; G Girolomoni
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical and experimental rheumatology     Volume:  24     ISSN:  0392-856X     ISO Abbreviation:  Clin. Exp. Rheumatol.     Publication Date:    2006 Jan-Feb
Date Detail:
Created Date:  2006-02-09     Completed Date:  2006-06-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8308521     Medline TA:  Clin Exp Rheumatol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  S1-6     Citation Subset:  IM    
Department of Dermatology, University of Münster, Münster, Germany.
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MeSH Terms
Antigens, CD40 / immunology
Autoantibodies / immunology
Autoimmune Diseases / immunology
CD40 Ligand / immunology
Chronic Disease
Dermatitis / immunology
Keratinocytes / immunology
Skin Diseases / immunology*
T-Lymphocytes / immunology
Reg. No./Substance:
0/Antigens, CD40; 0/Autoantibodies; 147205-72-9/CD40 Ligand

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