Document Detail


Mechanisms of hyponatraemia in alcohol patients.
MedLine Citation:
PMID:  11093969     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hyponatraemia is commonly reported in chronic alcoholic patients. However, the underlying pathogenetic mechanisms are not well delineated. In the current study, we analysed the possible pathophysiological mechanisms of hyponatraemia in a group of alcoholic patients (n = 127) admitted to our hospital for causes related to alcohol misuse. Hyponatraemia (serum sodium <134 mmol/l) was found in 22 patients (17.3%). The most common cause of hyponatraemia in our cohort was hypovolaemia (12 patients); pseudohyponatraemia was diagnosed in six patients with alcohol-induced severe hypertriglyceridaemia. It is of interest that two patients fulfilled the criteria of the so-called 'beer potomania' syndrome, while in two others, hyponatraemia was due to reset osmostat or to cerebral salt wasting syndrome, not previously described in alcoholic patients. It is concluded that hyponatraemia is a frequently observed electrolyte disorder in hospitalized alcoholic patients and is related to various pathophysiological mechanisms.
Authors:
G L Liamis; H J Milionis; E C Rizos; K C Siamopoulos; M S Elisaf
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Alcohol and alcoholism (Oxford, Oxfordshire)     Volume:  35     ISSN:  0735-0414     ISO Abbreviation:  Alcohol Alcohol.     Publication Date:    2000 Nov-Dec
Date Detail:
Created Date:  2001-02-02     Completed Date:  2001-02-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8310684     Medline TA:  Alcohol Alcohol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  612-6     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Medical School, University of Ioannina, 45110 Ioannina, Greece.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Alcoholism / complications*,  physiopathology
Blood Chemical Analysis
Female
Humans
Hyponatremia / diagnosis,  etiology*,  physiopathology
Male
Middle Aged
Prospective Studies
Urinalysis

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