| Mechanisms of hypertension in obesity. | |
| | |
MedLine Citation:
|
PMID: 3323617 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We conclude that the following may explain the rise in blood pressure with obesity and the subsequent fall in blood pressure (Fig. 2): (1) An increase in calories, protein, or carbohydrate leads to an increase in plasma catecholamines, sympathetic nervous system activity, and insulin secretion. (2) These factors, in turn, lead to increased renal sodium retention and stimulation of the renin-aldosterone system which, in turn, leads to: (3) An increased cardiac output with an inability to appropriately adjust the peripheral resistance to maintain normotension with resultant hypertension. Conversely, the fall in blood pressure with weight reduction can be explained by (Fig. 3): (1) A decrease in calorie, carbohydrate, or protein intake which leads to: (2) A decrease in circulating plasma catecholamines, sympathetic nervous system activity, and insulin secretion which results in: (3) A natriuresis and decrease in the renin-aldosterone system, which causes a decrease in circulating blood volume and in cardiac output. This, in turn, lowers blood pressure towards normal. The unanswered question still remains: why do some obese patients become hypertensive and others remain normotensive? Perhaps there are weight-sensitive individuals and weight-resistant individuals just as there appear to be salt-sensitive and salt-resistant hypertensive patients. Perhaps the answer is genetic. These questions also remain to be answered. |
| | |
Authors:
|
L P Dornfeld; M H Maxwell; A Waks; M Tuck |
Related Documents
:
|
11790287 - Genetics of the mineralocorticoid system in primary hypertension. 18314347 - Primary aldosteronism: cardiovascular, renal and metabolic implications. 6509787 - The blood pressure and metabolic effects of 19-nor-deoxycorticosterone and 19-nor-proge... 18268147 - Association of leukocyte telomere length with circulating biomarkers of the renin-angio... 20545837 - Obstructive sleep apnoea and 24-h blood pressure in patients with resistant hypertension. 6368497 - Lung compliance changes on high-frequency ventilation in normal dogs. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Kidney international. Supplement Volume: 22 ISSN: 0098-6577 ISO Abbreviation: Kidney Int. Suppl. Publication Date: 1987 Oct |
Date Detail:
|
Created Date: 1988-02-26 Completed Date: 1988-02-26 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7508622 Medline TA: Kidney Int Suppl Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: S254-8 Citation Subset: IM |
Affiliation:
|
School of Medicine University of California, Los Angeles 90024. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenal Glands
/
physiopathology Female Humans Hypertension / etiology* Insulin / physiology Obesity / complications* Renin-Angiotensin System Sodium / physiology Sympathetic Nervous System / physiopathology |
| Chemical | |
Reg. No./Substance:
|
11061-68-0/Insulin; 7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Controlled trial of two keto acid supplements on renal function, nutritional status, and bone metabo...
Next Document: The roles of eicosanoids in experimental glomerulonephritis.