| Mechanisms of hypertension associated with obesity. | |
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MedLine Citation:
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PMID: 6342497 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Epidemiologic studies suggest that obesity is a major factor in hypertension in industrialized societies. Possible mechanisms for this association include elevated cardiac output, increased body sodium due to hyperinsulinemia or abnormal aldosterone/renin relationships, and neuroendocrine abnormalities due to increased noradrenergic activity or opiate suppression. Although cardiac output and plasma volume of obese hypertensive patients are not different from what is found in non-obese persons when expressed in relation to body surface area, these results are from cross-sectional studies and do not relate to the effects of weight gain on arterial pressure. The role of hyperinsulinemia and that of other endocrine or neuroendocrine abnormalities have not been studied extensively enough for the association to be proved. |
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Authors:
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H P Dustan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of internal medicine Volume: 98 ISSN: 0003-4819 ISO Abbreviation: Ann. Intern. Med. Publication Date: 1983 May |
Date Detail:
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Created Date: 1983-06-10 Completed Date: 1983-06-10 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372351 Medline TA: Ann Intern Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 860-4 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure Blood Volume Body Weight Cardiac Output Central Nervous System / physiopathology Extracellular Space / physiology Female Humans Hypertension / complications, physiopathology* Insulin / physiology Male Obesity / complications*, physiopathology Rats Vascular Resistance |
| Chemical | |
Reg. No./Substance:
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11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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