Document Detail


Mechanisms of hypertension associated with obesity.
MedLine Citation:
PMID:  6342497     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Epidemiologic studies suggest that obesity is a major factor in hypertension in industrialized societies. Possible mechanisms for this association include elevated cardiac output, increased body sodium due to hyperinsulinemia or abnormal aldosterone/renin relationships, and neuroendocrine abnormalities due to increased noradrenergic activity or opiate suppression. Although cardiac output and plasma volume of obese hypertensive patients are not different from what is found in non-obese persons when expressed in relation to body surface area, these results are from cross-sectional studies and do not relate to the effects of weight gain on arterial pressure. The role of hyperinsulinemia and that of other endocrine or neuroendocrine abnormalities have not been studied extensively enough for the association to be proved.
Authors:
H P Dustan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of internal medicine     Volume:  98     ISSN:  0003-4819     ISO Abbreviation:  Ann. Intern. Med.     Publication Date:  1983 May 
Date Detail:
Created Date:  1983-06-10     Completed Date:  1983-06-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372351     Medline TA:  Ann Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  860-4     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure
Blood Volume
Body Weight
Cardiac Output
Central Nervous System / physiopathology
Extracellular Space / physiology
Female
Humans
Hypertension / complications,  physiopathology*
Insulin / physiology
Male
Obesity / complications*,  physiopathology
Rats
Vascular Resistance
Chemical
Reg. No./Substance:
11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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