Document Detail

Mechanisms of histone H3 lysine 27 trimethylation remodeling during early mammalian development.
MedLine Citation:
PMID:  22895114     Owner:  NLM     Status:  MEDLINE    
During fertilization, two of the most differentiated cells in the mammalian organism, a sperm and oocyte, are combined to form a pluripotent embryo. Dynamic changes in chromatin structure allow the transition of the chromatin on these specialized cells into an embryonic configuration capable of generating every cell type. Initially, this reprogramming activity is supported by oocyte-derived factors accumulated during oogenesis as proteins and mRNAs; however, the underlying molecular mechanisms that govern it remain poorly characterized. Trimethylation of histone H3 at lysine 27 (H3K27me3) is a repressive epigenetic mark that changes dynamically during pre-implantation development in mice, bovine and pig embryos. Here we present data and hypotheses related to the potential mechanisms behind H3K27me3 remodeling during early development. We postulate that the repressive H3K27me3 mark is globally erased from the parental genomes in order to remove the gametic epigenetic program and to establish a pluripotent embryonic epigenome. We discuss information gathered in mice, pigs, and bovine, with the intent of providing a comparative analysis of the reprogramming of this epigenetic mark during early mammalian development.
Yanina S Bogliotti; Pablo J Ross
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-08-16
Journal Detail:
Title:  Epigenetics : official journal of the DNA Methylation Society     Volume:  7     ISSN:  1559-2308     ISO Abbreviation:  Epigenetics     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-10-01     Completed Date:  2013-06-14     Revised Date:  2013-09-03    
Medline Journal Info:
Nlm Unique ID:  101265293     Medline TA:  Epigenetics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  976-81     Citation Subset:  IM    
Department of Animal Science, University of California, Davis, Davis, CA, USA.
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MeSH Terms
Chromatin Assembly and Disassembly*
Embryonic Development / genetics*
Gene Expression Regulation, Developmental
Histones / genetics,  metabolism*
Lysine / metabolism*
Nuclear Reprogramming
Protein Processing, Post-Translational
Grant Support
Reg. No./Substance:
0/Histones; 56-87-1/Lysine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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