Document Detail


Mechanisms of heart failure in obesity.
MedLine Citation:
PMID:  25434909     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Heart failure is a leading cause of morbidity and mortality and its prevalence continues to rise. Because obesity has been linked with heart failure, the increasing prevalence of obesity may presage further rise in heart failure in the future. Obesity-related factors are estimated to cause 11% of heart failure cases in men and 14% in women. Obesity may result in heart failure by inducing haemodynamic and myocardial changes that lead to cardiac dysfunction, or due to an increased predisposition to other heart failure risk factors. Direct cardiac lipotoxicity has been described where lipid accumulation in the heart results in cardiac dysfunction inexplicable of other heart failure risk factors. In this overview, we discussed various pathophysiological mechanisms that could lead to heart failure in obesity, including the molecular mechanisms underlying cardiac lipotoxicity. We defined the obesity paradox and enumerated various premises for the paradoxical associations observed in the relationship between obesity and heart failure.
Authors:
Imo A Ebong; David C Goff; Carlos J Rodriguez; Haiying Chen; Alain G Bertoni
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Publication Detail:
Type:  REVIEW     Date:  2014-1-6
Journal Detail:
Title:  Obesity research & clinical practice     Volume:  8     ISSN:  1871-403X     ISO Abbreviation:  Obes Res Clin Pract     Publication Date:    2014 November - December
Date Detail:
Created Date:  2014-12-1     Completed Date:  -     Revised Date:  2014-12-2    
Medline Journal Info:
Nlm Unique ID:  101303911     Medline TA:  Obes Res Clin Pract     Country:  -    
Other Details:
Languages:  ENG     Pagination:  e540-e548     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
T32 HL087730/HL/NHLBI NIH HHS

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