Document Detail


Mechanisms of heart development in the Japanese lamprey, Lethenteron japonicum.
MedLine Citation:
PMID:  20156281     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Vertebrate hearts have evolved from undivided tubular hearts of chordate ancestors. One of the most intriguing issues in heart evolution is the abrupt appearance of multichambered hearts in the agnathan vertebrates. To explore the developmental mechanisms behind the drastic morphological changes that led to complex vertebrate hearts, we examined the developmental patterning of the agnathan lamprey Lethenteron japonicum. We isolated lamprey orthologs of genes thought to be essential for heart development in chicken and mouse embryos, including genes responsible for differentiation and proliferation of the myocardium (LjTbx20, LjTbx4/5, and LjIsl1/2A), establishment of left-right heart asymmetry (LjPitxA), and partitioning of the heart tube (LjTbx2/3A), and studied their expression patterns during lamprey cardiogenesis. We confirmed the presence of the cardiac progenitors expressing LjIsl1/2A in the pharyngeal and splanchnic mesoderm and the heart tube of the lamprey. The presence of LjIsl1/2A-positive cardiac progenitor cells in cardiogenesis may have permitted an increase of myocardial size in vertebrates. We also observed LjPitxA expression in the left side of lamprey cardiac mesoderm, suggesting that asymmetric expression of Pitx in the heart has been acquired in the vertebrate lineage. Additionally, we observed LjTbx2/3A expression in the nonchambered myocardium, supporting the view that acquisition of Tbx2/3 expression may have allowed primitive tubular hearts to partition, giving rise to multichambered hearts.
Authors:
Nobuhiro Kokubo; Manami Matsuura; Koh Onimaru; Eva Tiecke; Shigehiro Kuraku; Shigeru Kuratani; Mikiko Tanaka
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Evolution & development     Volume:  12     ISSN:  1525-142X     ISO Abbreviation:  Evol. Dev.     Publication Date:    2010 Jan-Feb
Date Detail:
Created Date:  2010-02-16     Completed Date:  2010-05-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883432     Medline TA:  Evol Dev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  34-44     Citation Subset:  IM    
Affiliation:
Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Midori-ku, Yokohama, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Patterning / genetics
Chick Embryo
Evolution
Female
Gene Expression Regulation, Developmental
Genes, Homeobox
Heart / embryology*
In Situ Hybridization
Lampreys / embryology*,  genetics
Male
Mice
Models, Cardiovascular
Myocardium / metabolism
Species Specificity
T-Box Domain Proteins / genetics
Chemical
Reg. No./Substance:
0/T-Box Domain Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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