| Mechanisms of heart development in the Japanese lamprey, Lethenteron japonicum. | |
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MedLine Citation:
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PMID: 20156281 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Vertebrate hearts have evolved from undivided tubular hearts of chordate ancestors. One of the most intriguing issues in heart evolution is the abrupt appearance of multichambered hearts in the agnathan vertebrates. To explore the developmental mechanisms behind the drastic morphological changes that led to complex vertebrate hearts, we examined the developmental patterning of the agnathan lamprey Lethenteron japonicum. We isolated lamprey orthologs of genes thought to be essential for heart development in chicken and mouse embryos, including genes responsible for differentiation and proliferation of the myocardium (LjTbx20, LjTbx4/5, and LjIsl1/2A), establishment of left-right heart asymmetry (LjPitxA), and partitioning of the heart tube (LjTbx2/3A), and studied their expression patterns during lamprey cardiogenesis. We confirmed the presence of the cardiac progenitors expressing LjIsl1/2A in the pharyngeal and splanchnic mesoderm and the heart tube of the lamprey. The presence of LjIsl1/2A-positive cardiac progenitor cells in cardiogenesis may have permitted an increase of myocardial size in vertebrates. We also observed LjPitxA expression in the left side of lamprey cardiac mesoderm, suggesting that asymmetric expression of Pitx in the heart has been acquired in the vertebrate lineage. Additionally, we observed LjTbx2/3A expression in the nonchambered myocardium, supporting the view that acquisition of Tbx2/3 expression may have allowed primitive tubular hearts to partition, giving rise to multichambered hearts. |
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Authors:
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Nobuhiro Kokubo; Manami Matsuura; Koh Onimaru; Eva Tiecke; Shigehiro Kuraku; Shigeru Kuratani; Mikiko Tanaka |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Evolution & development Volume: 12 ISSN: 1525-142X ISO Abbreviation: Evol. Dev. Publication Date: 2010 Jan-Feb |
Date Detail:
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Created Date: 2010-02-16 Completed Date: 2010-05-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883432 Medline TA: Evol Dev Country: United States |
Other Details:
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Languages: eng Pagination: 34-44 Citation Subset: IM |
Affiliation:
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Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Midori-ku, Yokohama, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Patterning / genetics Chick Embryo Evolution Female Gene Expression Regulation, Developmental Genes, Homeobox Heart / embryology* In Situ Hybridization Lampreys / embryology*, genetics Male Mice Models, Cardiovascular Myocardium / metabolism Species Specificity T-Box Domain Proteins / genetics |
| Chemical | |
Reg. No./Substance:
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0/T-Box Domain Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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