| Mechanisms of glucocorticoids in the control of neuroinflammation. | |
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MedLine Citation:
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PMID: 21615563 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Glucocorticoids (GC) are widely used to treat inflammatory diseases such as multiple sclerosis (MS). They predominantly act through the GC receptor (GR), a member of the nuclear receptor superfamily that controls transcription by several different mechanisms. Owing to its ubiquitous expression there are a variety of cell types that could serve as GC targets in the pathogenesis and treatment of MS. This brings about a great diversity of mechanisms potentially involved in the modulation of neuroinflammation by GC including the induction of apoptosis, repression of pro-inflammatory mediators and expansion of myeloid derived suppressor cells. Nevertheless, it is not well understood which of these mechanisms are essential for therapeutic efficacy. In this review we summarize findings made concerning GC actions in MS and its animal model experimental autoimmune encephalomyelitis (EAE), and elucidate current concepts and developments that pertain this clinically highly relevant treatment regimen. |
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Authors:
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Nils Schweingruber; Sybille D Reichardt; Fred Lühder; Holger M Reichardt |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-25 |
Journal Detail:
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Title: Journal of neuroendocrinology Volume: - ISSN: 1365-2826 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8913461 Medline TA: J Neuroendocrinol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Journal of Neuroendocrinology © 2011 Blackwell Publishing. |
Affiliation:
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Department of Cellular and Molecular Immunology, University of Göttingen Medical School, Germany Department of Neuroimmunology, University of Göttingen Medical School, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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