Document Detail

Mechanisms of gastroesophageal reflux in children with sequelae of birth asphyxia.
MedLine Citation:
PMID:  18328656     Owner:  NLM     Status:  MEDLINE    
RESULTS: Esophageal manometry and pH monitoring were conducted for a mean duration of 91.5 min. Basal LES pressure averaged (+/-SD) 9.2+/-4.8 mmHg; in 4 of 10 patients (40%) the LES pressure was largely undetectable, varying between 0 and 2 mmHg. Mean LES pressure was inversely correlated with age (r=0.7, P=0.02). The total number of reflux episodes/h averaged 32.1+/-12.1 LES pressure reached 0 mmHg in 98% of reflux episodes. Type I LES relaxations were present in 3.15+/-1.1 reflux episodes/h, whereas type II LES relaxation occurred in 2.3+/-2.4 episodes/h. Acid reflux episodes appeared during absent basal LES tone periods, without phasic LES relaxations, in 74%.
CONCLUSIONS: Absent basal LES tone is the main mechanism of GER in a subgroup of NIC, especially in older children. Transient LES relaxation, the most common known event associated with acid reflux in neurologically normal children, seems to precede a minority of reflux events in NIC.
Licia Pensabene; Erasmo Miele; Ennio Del Giudice; Caterina Strisciuglio; Annamaria Staiano
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Publication Detail:
Type:  Journal Article     Date:  2008-03-06
Journal Detail:
Title:  Brain & development     Volume:  30     ISSN:  0387-7604     ISO Abbreviation:  Brain Dev.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-08-26     Completed Date:  2008-10-15     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  7909235     Medline TA:  Brain Dev     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  563-71     Citation Subset:  IM    
Department of Pediatrics, University Magna Graecia of Catanzaro, Italy.
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MeSH Terms
Asphyxia Neonatorum / complications*
Child, Preschool
Esophageal Motility Disorders / etiology,  physiopathology
Esophageal Sphincter, Lower / physiology*
Gastroesophageal Reflux* / etiology,  physiopathology
Hydrogen-Ion Concentration
Infant, Newborn

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