| Mechanisms of extrahepatic vasodilation in portal hypertension. | |
| | |
MedLine Citation:
|
PMID: 18445644 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In liver cirrhosis, abnormal persistent extrahepatic vasodilation leads to hyperdynamic circulatory dysfunction which essentially contributes to portal hypertension. Since portal hypertension is a major factor in the development of complications in cirrhosis, the mechanisms underlying this vasodilation are of paramount interest. Extensive studies performed in cirrhotic patients and animals revealed that this vasodilation is associated on the one hand with enhanced formation of vasodilators, and on the other hand with vascular hyporesponsiveness to vasoconstrictors. The latter phenomenon has been termed "vascular hypocontractility". It is caused by a combination of different mechanisms and factors described in this review. |
| | |
Authors:
|
M Hennenberg; J Trebicka; T Sauerbruch; J Heller |
Related Documents
:
|
1973334 - Current status and future goals of the pharmacologic reduction of portal hypertension. 17975474 - Molecular mechanisms of increased intrahepatic resistance in portal hypertension. 15486224 - Modification of the terminal residue of apelin-13 antagonizes its hypotensive action. 3130174 - Catecholamine and blood pressure regulation by gonadotropin-releasing hormone analogs i... 21431424 - Acute effects of walking in forest environments on cardiovascular and metabolic paramet... 19726694 - Sensing of blood pressure increase by transient receptor potential vanilloid 1 receptor... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2008-04-29 |
Journal Detail:
|
Title: Gut Volume: 57 ISSN: 1468-3288 ISO Abbreviation: Gut Publication Date: 2008 Sep |
Date Detail:
|
Created Date: 2008-08-22 Completed Date: 2008-09-04 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 2985108R Medline TA: Gut Country: England |
Other Details:
|
Languages: eng Pagination: 1300-14 Citation Subset: AIM; IM |
Affiliation:
|
Department of Internal Medicine I, University of Bonn, Sigmund-Freud-Str. 25, D-53105 Bonn, Germany. Martin.Hennenberg@ukb.uni-bonn.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Endocannabinoids
/
physiology Humans Hypertension, Portal / etiology*, physiopathology* Liver Cirrhosis / complications*, physiopathology Muscle, Smooth, Vascular / physiopathology Nitric Oxide / physiology Signal Transduction Splanchnic Circulation Vasodilation* |
| Chemical | |
Reg. No./Substance:
|
0/Endocannabinoids; 10102-43-9/Nitric Oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Will generalist physician supply meet demands of an increasing and aging population?
Next Document: Development of a multiplex quantitative fluorescent PCR assay for identification of rearrangements i...