Document Detail

Mechanisms of extrahepatic vasodilation in portal hypertension.
MedLine Citation:
PMID:  18445644     Owner:  NLM     Status:  MEDLINE    
In liver cirrhosis, abnormal persistent extrahepatic vasodilation leads to hyperdynamic circulatory dysfunction which essentially contributes to portal hypertension. Since portal hypertension is a major factor in the development of complications in cirrhosis, the mechanisms underlying this vasodilation are of paramount interest. Extensive studies performed in cirrhotic patients and animals revealed that this vasodilation is associated on the one hand with enhanced formation of vasodilators, and on the other hand with vascular hyporesponsiveness to vasoconstrictors. The latter phenomenon has been termed "vascular hypocontractility". It is caused by a combination of different mechanisms and factors described in this review.
M Hennenberg; J Trebicka; T Sauerbruch; J Heller
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-04-29
Journal Detail:
Title:  Gut     Volume:  57     ISSN:  1468-3288     ISO Abbreviation:  Gut     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-22     Completed Date:  2008-09-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  England    
Other Details:
Languages:  eng     Pagination:  1300-14     Citation Subset:  AIM; IM    
Department of Internal Medicine I, University of Bonn, Sigmund-Freud-Str. 25, D-53105 Bonn, Germany.
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MeSH Terms
Endocannabinoids / physiology
Hypertension, Portal / etiology*,  physiopathology*
Liver Cirrhosis / complications*,  physiopathology
Muscle, Smooth, Vascular / physiopathology
Nitric Oxide / physiology
Signal Transduction
Splanchnic Circulation
Reg. No./Substance:
0/Endocannabinoids; 10102-43-9/Nitric Oxide

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