| Mechanisms for the establishment of pregnancy in the pig. | |
| | |
MedLine Citation:
|
PMID: 21854459 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Establishment of pregnancy in pigs requires continuous function of corpora lutea and endometrial preparation for embryo implantation. Progesterone regulates expression of many proteins necessary for endometrial remodelling and embryo-maternal communications. Attaining the uterine receptivity involves progesterone priming and loss of progesterone receptors in the uterine epithelium before days 10-12 after oestrus. Spermatozoa and oocytes in oviduct alter secretion of specific proteins that exert beneficial effect on gametes and embryos. Moreover, an appropriate leucocyte activation and maintenance of delicate cytokine balance within the oviduct and uterus are important for early pregnancy. This early local immune response is rather mediated by seminal plasma components. These components also influence prostaglandin (PG) synthesis in the oviduct that is important for gamete and embryo transport. Pregnancy establishment requires the biphasic pattern of oestrogen secretion by conceptuses on days 11-12 and 15-30. Conceptus affects lipid signalling system consisting of prostaglandins and lysophosphatic acid. PG synthesis is changed by conceptus signals in favour of luteoprotective PGE(2) . Additionally, existence of PGE(2) positive feedback loop in the endometrium contributes to increased PGE(2) /PGF(2α) ratio during the peri-implantation period. PGE(2) through endometrial PGE(2) receptor (PTGER2) elevates the expression of enzymes involved in PGE(2) synthesis. Higher PGE(2) secretion in uterine lumen coincides with the elevated expression of HOXA10 transcription factor critical for implantation. A stable adhesion between conceptus and endometrium requires reduction in mucin-1 on the apical surface of epithelium and integrin activation by extracellular matrix proteins. Furthermore, growth factors, cytokines and its receptors are involved in embryo-maternal interactions. |
| | |
Authors:
|
Aj Ziecik; A Waclawik; Mm Kaczmarek; A Blitek; B Moza Jalali; A Andronowska |
Related Documents
:
|
19960559 - Acute pancreatitis in pregnancy. 300729 - Radioresistance of mongolian gerbils. fast neutrons. 21921969 - Predictors and consequences of adolescents' norms against teenage pregnancy. 21861949 - Does vitamin d during pregnancy impact offspring growth and bone? 22199039 - On the safety of diagnostic ultrasound in pregnancy: have we handled the available data... 7041949 - A comparative study of toxic erythema of pregnancy and herpes gestationis. 21597239 - Developmental ability of somatic cell nuclear transferred embryos aggregated at the 8-c... 6419969 - Obstruction of the fetal urinary tract: a role for surgical intervention in utero? 19471289 - Glucose kinetics and pregnancy outcome in indian women with low and normal body mass in... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Reproduction in domestic animals = Zuchthygiene Volume: 46 Suppl 3 ISSN: 1439-0531 ISO Abbreviation: Reprod. Domest. Anim. Publication Date: 2011 Sep |
Date Detail:
|
Created Date: 2011-08-22 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9015668 Medline TA: Reprod Domest Anim Country: Germany |
Other Details:
|
Languages: eng Pagination: 31-41 Citation Subset: IM |
Copyright Information:
|
© 2011 Blackwell Verlag GmbH. |
Affiliation:
|
Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Tuwima, Olsztyn, Poland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The immunology of early pregnancy in farm animals.
Next Document: Golden perspective: application of laser-generated gold nanoparticle conjugates in reproductive biol...