Document Detail


Mechanisms of enteral nutrient-enhanced intestinal adaptation.
MedLine Citation:
PMID:  16473079     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The role of enteral nutrients in maintaining small intestinal structure and function is well established. Evidence that enteral nutrients induce intestinal adaptation include the structural and functional gradient along the length of the healthy intestine, the atrophy and functional compromise induced by fasting and parenteral nutrition, and the enhanced adaptive capacity of the distal intestine following partial enterectomy. Key mechanisms contributing to enteral nutrient-induced intestinal adaptation include nonspecific luminal stimulation and that provided by specific nutrients, "functional workload" induced by polymeric nutrients, potential stimulation of pancreaticobiliary secretions, secretion of humoral mediators, and induction of intestinal hyperemia.
Authors:
Kelly A Tappenden
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Gastroenterology     Volume:  130     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-02-13     Completed Date:  2006-03-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S93-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Food Science and Human Nutrition, Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA. tappende@uiuc.edu
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological / physiology*
Atrophy / etiology
Enteral Nutrition*
Fasting / physiology
Humans
Intestinal Absorption / physiology*
Intestine, Small / pathology*,  physiopathology*
Parenteral Nutrition / adverse effects
Grant Support
ID/Acronym/Agency:
5R01-DK057682/DK/NIDDK NIH HHS
Comments/Corrections
Comment In:
Gastroenterology. 2006 Feb;130(2 Suppl 1):S91-2   [PMID:  16473078 ]

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