Document Detail

Mechanisms of endothelial senescence.
MedLine Citation:
PMID:  18931048     Owner:  NLM     Status:  MEDLINE    
When endothelial cells from different vascular beds are grown in culture they show a limited capacity to divide, eventually entering into a permanent and phenotypically distinctive non-dividing state referred to as 'replicative senescence'. Replicative senescence is thought to result from progressive shortening of telomeric DNA and consequent telomere dysfunction. More recently, it has been realised that senescence can also be induced by a variety of insults, including those causing intracellular oxidative stress. In this report, we review evidence for the occurrence of endothelial cell senescence in vivo. We will also examine the causes, mechanisms and regulation of this process as they emerge from our studies in cell culture, focusing in particular on the roles of oxidative stress, telomerase, growth factors and nitric oxide.
Jorge D Erusalimsky; Chris Skene
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-10-17
Journal Detail:
Title:  Experimental physiology     Volume:  94     ISSN:  1469-445X     ISO Abbreviation:  Exp. Physiol.     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-02-24     Completed Date:  2009-04-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9002940     Medline TA:  Exp Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  299-304     Citation Subset:  IM    
Cardiff School of Health Sciences, University of Wales Institute Cardiff, Western Avenue, Cardiff CF52YB, UK.
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MeSH Terms
Cell Aging / physiology*
Cell Division / physiology
Cells, Cultured
Endothelium, Vascular / cytology*,  physiology*
Nitric Oxide / physiology
Oxidative Stress / physiology
Telomerase / physiology
Telomere / physiology
Grant Support
FS/04/031//British Heart Foundation
Reg. No./Substance:
10102-43-9/Nitric Oxide; EC

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