Document Detail

Mechanisms of early and late hypermetabolism and fever after localized tissue injury in rats.
MedLine Citation:
PMID:  1685068     Owner:  NLM     Status:  MEDLINE    
Inflammation and localized tissue injury were induced in rats by intramuscular injection of turpentine. This caused rapid and sustained (2-24 h) increases in colonic temperature (Tc; up by 2.5 degrees C) and oxygen consumption (VO2; up by 30%) as well as hypophagia (57%). The early responses (0-2 h) were attenuated by anesthesia, C-fiber deafferentation, peripheral but not central injection of a cyclooxygenase inhibitor, or central injection of a neutralizing antibody to corticotropin-releasing factor (CRF). In contrast, the later (18-20 h) changes in Tc and VO2 were unaffected by anesthesia, C-fiber deafferentation, or central injection of a CRF antibody but were inhibited by either peripheral or central administration of a cyclooxygenase inhibitor. beta-Adrenoceptor blockade reduced both phases of the response, and brown adipose tissue activity was significantly elevated from 4 to 24 h after turpentine injection. These data suggest that different mechanisms mediate the metabolic response to localized tissue injury, the early phase involving neural mechanisms characteristic of stress and inflammation, whereas the later phase appears to depend on humoral factors that are commonly associated with infection.
A L Cooper; N J Rothwell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  261     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1992-02-14     Completed Date:  1992-02-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  E698-705     Citation Subset:  IM    
Department of Physiological Sciences, University of Manchester, United Kingdom.
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MeSH Terms
Adrenergic beta-Antagonists / pharmacology
Analysis of Variance
Capsaicin / pharmacology
Central Nervous System / drug effects,  metabolism
Corticotropin-Releasing Hormone / immunology,  metabolism
Eating / drug effects
Fever / etiology*,  metabolism
Flurbiprofen / pharmacology
Inflammation / metabolism*
Injections, Intramuscular
Oxygen Consumption / drug effects
Peripheral Nerves / drug effects,  metabolism
Propranolol / pharmacology
Rats, Inbred Strains
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Antibodies; 404-86-4/Capsaicin; 5104-49-4/Flurbiprofen; 525-66-6/Propranolol; 8006-64-2/Turpentine; 9015-71-8/Corticotropin-Releasing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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