| Mechanisms of dyspnoea and its language in patients with asthma. | |
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MedLine Citation:
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PMID: 16585080 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study hypothesises that regardless of the global score of dyspnoea intensity, different descriptors may be selected by asthmatic patients during short cardiopulmonary exercise test (sCPET) and methacholine (Mch) inhalation. It also examines whether different qualitative dyspnoea sensations can help explain the underlying mechanisms of the symptom. Minute ventilation (V'E), tidal volume (VT) and inspiratory capacity (IC) were measured in 22 stable asthmatic patients, and the sensation of dyspnoea during Mch inhalation and sCPET was quantitatively (Borg scale) and qualitatively (descriptors) assessed. The work rate and oxygen uptake (V'O2) were also measured during sCPET. Airway obstruction and hyperinflation, as measured by IC reduction, were the best correlates for dyspnoea with Mch. During sCPET, changes in WR, V'O2, V'E and VT significantly correlated with Borg score, with V'E being the best predictor of dyspnoea; IC decreased in eight patients. Furthermore, chest tightness (68%) was the highest reported descriptor during Mch inhalation, whereas work/effort (72%) was the highest during sCPET. In conclusion, obstruction/hyperinflation and work rate are highly reliable predictors of Borg rating of dyspnoea during methacholine inhalation and short cardiopulmonary exercise testing, respectively. Regardless of the global score of intensity dyspnoea, different descriptors may be selected by patients during short cardiopulmonary exercise testing and methacholine inhalation. Various qualities of dyspnoea result from different pathophysiological abnormalities. |
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Authors:
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P Laveneziana; P Lotti; C Coli; B Binazzi; L Chiti; L Stendardi; R Duranti; G Scano |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology Volume: 27 ISSN: 0903-1936 ISO Abbreviation: Eur. Respir. J. Publication Date: 2006 Apr |
Date Detail:
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Created Date: 2006-04-04 Completed Date: 2006-10-11 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: Denmark |
Other Details:
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Languages: eng Pagination: 742-7 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, University of Florence, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Adult Aged Airway Obstruction / diagnosis, physiopathology, psychology Asthma / diagnosis, physiopathology, psychology* Bronchial Provocation Tests / psychology* Dyspnea / diagnosis, physiopathology, psychology* Exercise Test / psychology* Female Humans Lung Volume Measurements Male Methacholine Chloride / diagnostic use* Middle Aged Physical Exertion / physiology Psychophysics Sick Role* Spirometry |
| Chemical | |
Reg. No./Substance:
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62-51-1/Methacholine Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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