Document Detail

Mechanisms of dyspnoea and its language in patients with asthma.
MedLine Citation:
PMID:  16585080     Owner:  NLM     Status:  MEDLINE    
This study hypothesises that regardless of the global score of dyspnoea intensity, different descriptors may be selected by asthmatic patients during short cardiopulmonary exercise test (sCPET) and methacholine (Mch) inhalation. It also examines whether different qualitative dyspnoea sensations can help explain the underlying mechanisms of the symptom. Minute ventilation (V'E), tidal volume (VT) and inspiratory capacity (IC) were measured in 22 stable asthmatic patients, and the sensation of dyspnoea during Mch inhalation and sCPET was quantitatively (Borg scale) and qualitatively (descriptors) assessed. The work rate and oxygen uptake (V'O2) were also measured during sCPET. Airway obstruction and hyperinflation, as measured by IC reduction, were the best correlates for dyspnoea with Mch. During sCPET, changes in WR, V'O2, V'E and VT significantly correlated with Borg score, with V'E being the best predictor of dyspnoea; IC decreased in eight patients. Furthermore, chest tightness (68%) was the highest reported descriptor during Mch inhalation, whereas work/effort (72%) was the highest during sCPET. In conclusion, obstruction/hyperinflation and work rate are highly reliable predictors of Borg rating of dyspnoea during methacholine inhalation and short cardiopulmonary exercise testing, respectively. Regardless of the global score of intensity dyspnoea, different descriptors may be selected by patients during short cardiopulmonary exercise testing and methacholine inhalation. Various qualities of dyspnoea result from different pathophysiological abnormalities.
P Laveneziana; P Lotti; C Coli; B Binazzi; L Chiti; L Stendardi; R Duranti; G Scano
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The European respiratory journal     Volume:  27     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-04-04     Completed Date:  2006-10-11     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  742-7     Citation Subset:  IM    
Department of Internal Medicine, University of Florence, Italy.
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MeSH Terms
Administration, Inhalation
Airway Obstruction / diagnosis,  physiopathology,  psychology
Asthma / diagnosis,  physiopathology,  psychology*
Bronchial Provocation Tests / psychology*
Dyspnea / diagnosis,  physiopathology,  psychology*
Exercise Test / psychology*
Lung Volume Measurements
Methacholine Chloride / diagnostic use*
Middle Aged
Physical Exertion / physiology
Sick Role*
Reg. No./Substance:
62-51-1/Methacholine Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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