Document Detail


Mechanisms driving neural crest induction and migration in the zebrafish and Xenopus laevis.
MedLine Citation:
PMID:  20962584     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The neural crest is an evolutionary adaptation, with roots in the formation of mesoderm. Modification of neural crest behavior has been is critical for the evolutionary diversification of the vertebrates and defects in neural crest underlie a range of human birth defects. There has been a tremendous increase in our knowledge of the molecular, cellular, and inductive interactions that converge on defining the neural crest and determining its behavior. While there is a temptation to look for simple models to explain neural crest behavior, the reality is that the system is complex in its circuitry. In this review, our goal is to identify the broad features of neural crest origins (developmentally) and migration (cellularly) using data from the zebrafish (teleost) and Xenopus laevis (tetrapod amphibian) in order to illuminate where general mechanisms appear to be in play, and equally importantly, where disparities in experimental results suggest areas of profitable study.
Authors:
Michael W Klymkowsky; Christy Cortez Rossi; Kristin Bruk Artinger
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Cell adhesion & migration     Volume:  4     ISSN:  1933-6926     ISO Abbreviation:  Cell Adh Migr     Publication Date:    2010 Oct-Dec
Date Detail:
Created Date:  2011-04-18     Completed Date:  2011-06-21     Revised Date:  2014-03-27    
Medline Journal Info:
Nlm Unique ID:  101469464     Medline TA:  Cell Adh Migr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  595-608     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Movement*
Epithelial-Mesenchymal Transition
Gene Expression Regulation, Developmental
Intracellular Signaling Peptides and Proteins / metabolism
Mesoderm / metabolism
Neural Crest / cytology,  metabolism*
Phylogeny
Signal Transduction
Wnt Proteins / metabolism
Xenopus laevis / embryology*,  genetics
Zebrafish / embryology*,  genetics
Grant Support
ID/Acronym/Agency:
DE017699/DE/NIDCR NIH HHS; GM084133/GM/NIGMS NIH HHS; HD050695/HD/NICHD NIH HHS; R01 HD050698/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Intracellular Signaling Peptides and Proteins; 0/Wnt Proteins
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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