Document Detail

Mechanisms of disposal of acid and alkali in rabbit duodenum.
MedLine Citation:
PMID:  2019     Owner:  NLM     Status:  MEDLINE    
Stripped duodenal mucosa of rabbits was mounted in Ussing chambers containing a Ringer solution gassed with 100% O2. The disappearance of acid or alkali from the mucosal solution of short-circuited tissue was measured with a pH stat while the serosal pH was kept at 7.4. The duodenum rapidly disposed of both acid and alkali; neither property was altered by gassing with N2 while iodoacetate was in the perfusing solutions. Prevention of release of CO2 from the mucosal chamber obliterated the early rapid phase of acid disposal by the mucosa while a similar maneuver in the serosal chamber increased the appearance of serosal acid without altering the rate of acid disposal. Gut sacs of rabbit duodenum in vitro and in vivo showed a positive correlation between acid disposal and the rate of luminal CO2 production. While acid disposal progressively decreased with time for the in vitro gut sacs, the in vivo gut sac showed no fatigue in this respect. Luminal acidification in the Ussing chamber was associated with a profound reduction in short-circuit current (Isc), partially reversible by elevation of the mucosal pH but not by luminal glucose. Our data suggest that acid disposal occurs in part by intraluminal neutralization and in part by diffusion into the mucosa.
R G Fiddian-Green; W Silen
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  229     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1975 Dec 
Date Detail:
Created Date:  1976-03-20     Completed Date:  1976-03-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1641-8     Citation Subset:  IM    
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MeSH Terms
Acid-Base Equilibrium*
Bicarbonates / secretion
Biological Transport
Calcium / metabolism
Carbon Dioxide / metabolism
Cations, Divalent / metabolism
Duodenum / metabolism*
Hydrogen-Ion Concentration
Membrane Potentials
Mucous Membrane / metabolism
Potassium / metabolism
Sodium / metabolism
Reg. No./Substance:
0/Bicarbonates; 0/Cations, Divalent; 124-38-9/Carbon Dioxide; 7440-09-7/Potassium; 7440-23-5/Sodium; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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