Document Detail

Mechanisms of disease: high-grade prostatic intraepithelial neoplasia and other proposed preneoplastic lesions in the prostate.
MedLine Citation:
PMID:  17551536     Owner:  NLM     Status:  MEDLINE    
High-grade prostatic intraepithelial neoplasia (HGPIN) is the most likely precursor of prostatic adenocarcinoma according to virtually all available evidence. This lesion is characterized by cellular proliferations within pre-existing ducts and acini, with nuclear and nucleolar enlargements similar to those seen in prostate cancer, although unlike cancer HGPIN retains a basal-cell layer. The recognition of HGPIN is clinically important because of the strong association between this disease and prostatic carcinoma. The predictive value for cancer of an initial diagnosis of HGPIN on needle biopsy has substantially declined, with values falling from 36% to 21%. A major factor contributing to this decline is related to increased use of needle biopsy core sampling, which has provided the means for many cancers associated with HGPIN to be detected on initial biopsy; repeat biopsy, even with good sampling, does not detect many additional cancers. Other possible findings in the prostate might indicate premalignant disease (low-grade prostatic intraepithelial neoplasia, atrophy, malignancy-associated changes, and atypical adenomatous hyperplasia or adenosis), but the data for these premalignant diseases are much less convincing than those for HGPIN.
Rodolfo Montironi; Roberta Mazzucchelli; Antonio Lopez-Beltran; Liang Cheng; Marina Scarpelli
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Nature clinical practice. Urology     Volume:  4     ISSN:  1743-4289     ISO Abbreviation:  -     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-06-06     Completed Date:  2007-07-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101226508     Medline TA:  Nat Clin Pract Urol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  321-32     Citation Subset:  IM    
Uropathology Section, Institute of Pathological Anatomy and Histopathology, Polytechnic University of the Marche Region (Ancona), School of Medicine, United Hospitals, Torrette, Ancona, Italy.
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MeSH Terms
Adenocarcinoma / diagnosis,  pathology
Biopsy, Needle
Precancerous Conditions*
Predictive Value of Tests
Prostatic Intraepithelial Neoplasia / diagnosis*,  pathology*
Prostatic Neoplasms / diagnosis*,  pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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