Document Detail

Mechanisms of disease: the endocrinology of ectopic pregnancy.
MedLine Citation:
PMID:  22380790     Owner:  NLM     Status:  MEDLINE    
Ectopic pregnancy is defined as a pregnancy implanted outside the uterus, and >98% implant in the Fallopian tube. It has a major clinical and socioeconomic impact worldwide. The diagnosis of ectopic pregnancy is often difficult and resource intensive owing to a lack of accurate biomarkers, and there is a need for improved medical management of ectopic pregnancy using new or adjuvant treatments. The aetiology of ectopic pregnancy is uncertain, but tubal implantation is probably due to retention of the embryo in the Fallopian tube owing to impaired embryo-tubal transport and alterations in the tubal microenvironment. This comprehensive review of the literature supporting current understanding of the endocrinology of Fallopian tube biology and tubal implantation focuses on genes expressed in the Fallopian tube regulated by oestrogen and progesterone and discusses their potential functions. It concludes with a discussion of how advances in this field are enabling the development of novel biomarkers and could lead to the identification of potential new treatments for ectopic pregnancy.
Andrew W Horne; Hilary O D Critchley
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-03-02
Journal Detail:
Title:  Expert reviews in molecular medicine     Volume:  14     ISSN:  1462-3994     ISO Abbreviation:  Expert Rev Mol Med     Publication Date:  2012  
Date Detail:
Created Date:  2012-03-02     Completed Date:  2012-06-11     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  100939725     Medline TA:  Expert Rev Mol Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  e7     Citation Subset:  IM    
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MeSH Terms
Biological Markers / metabolism
Embryo Implantation*
Embryo, Mammalian / metabolism*,  pathology
Fallopian Tubes / metabolism*,  pathology
Gene Expression Regulation*
Pregnancy, Ectopic / diagnosis,  metabolism*,  pathology,  therapy
Grant Support
CZB/4/513//Chief Scientist Office; G0802808//Medical Research Council; G0802808 2009-13//Medical Research Council
Reg. No./Substance:
0/Biological Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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