| Mechanisms of diastolic dysfunction in heart failure. | |
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MedLine Citation:
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PMID: 17055383 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Abnormalities of diastole are common to most forms of congestive heart failure (HF). Diastolic function is broadly defined as the ability of the heart to fill adequately and at normal pressure to charge the ventricular pump for each subsequent contraction. It is determined by both active and passive processes occurring at the level of the myocyte, extracellular matrix, and left ventricular chamber. Forces extrinsic to the myocardium-such as the influence of right heart filling, pericardial and extracardiac constraints, and cardiac preload and afterload also contribute. Nearly half of patients with HF have apparently preserved systolic function, and this has focused attention on diastolic dysfunction as a dominant contributor to symptoms, sparking interest for understanding and treating diastolic abnormalities. This review focuses on the mechanisms determining normal and pathologic cardiac relaxation and distensibility and highlights how these abnormalities may be therapeutically targeted to improve diastolic function in human HF. |
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Authors:
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Barry A Borlaug; David A Kass |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Trends in cardiovascular medicine Volume: 16 ISSN: 1050-1738 ISO Abbreviation: Trends Cardiovasc. Med. Publication Date: 2006 Nov |
Date Detail:
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Created Date: 2006-10-23 Completed Date: 2007-02-08 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9108337 Medline TA: Trends Cardiovasc Med Country: United States |
Other Details:
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Languages: eng Pagination: 273-9 Citation Subset: IM |
Affiliation:
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Division of Cardiology, Department of Medicine, The Mayo Clinic College of Medicine, Rochester, MN 55905 USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Diastole
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physiology* Extracellular Matrix / physiology Heart / physiopathology Heart Failure / pathology, physiopathology*, therapy Humans Myocardium / pathology Stroke Volume / physiology |
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