Document Detail

Mechanisms of diastolic dysfunction in heart failure.
MedLine Citation:
PMID:  17055383     Owner:  NLM     Status:  MEDLINE    
Abnormalities of diastole are common to most forms of congestive heart failure (HF). Diastolic function is broadly defined as the ability of the heart to fill adequately and at normal pressure to charge the ventricular pump for each subsequent contraction. It is determined by both active and passive processes occurring at the level of the myocyte, extracellular matrix, and left ventricular chamber. Forces extrinsic to the myocardium-such as the influence of right heart filling, pericardial and extracardiac constraints, and cardiac preload and afterload also contribute. Nearly half of patients with HF have apparently preserved systolic function, and this has focused attention on diastolic dysfunction as a dominant contributor to symptoms, sparking interest for understanding and treating diastolic abnormalities. This review focuses on the mechanisms determining normal and pathologic cardiac relaxation and distensibility and highlights how these abnormalities may be therapeutically targeted to improve diastolic function in human HF.
Barry A Borlaug; David A Kass
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Trends in cardiovascular medicine     Volume:  16     ISSN:  1050-1738     ISO Abbreviation:  Trends Cardiovasc. Med.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-23     Completed Date:  2007-02-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9108337     Medline TA:  Trends Cardiovasc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  273-9     Citation Subset:  IM    
Division of Cardiology, Department of Medicine, The Mayo Clinic College of Medicine, Rochester, MN 55905 USA.
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MeSH Terms
Diastole / physiology*
Extracellular Matrix / physiology
Heart / physiopathology
Heart Failure / pathology,  physiopathology*,  therapy
Myocardium / pathology
Stroke Volume / physiology

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