| Mechanisms of defibrillation. Critical points and the upper limit of vulnerability. | |
| | |
MedLine Citation:
|
PMID: 8656095 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The upper limit of vulnerability hypothesis for defibrillation states that a successful defibrillation shock must both stop the fibrillation wave fronts on the heart at the time that the shock is delivered and not start new wave fronts that will lead to reentrant circuits being formed, causing the heart to refibrillate. Mapping studies have demonstrated that defibrillation shocks can halt all wave fronts on the heart but fibrillation will begin again with an initial activation pattern that is different from the activation pattern on the heart just before the shock is delivered. In a fashion similar to the reinitiation of fibrillation following a failed defibrillation shock, properly sized and timed shocks can be delivered to the heart during paced rhythm to induce functional reentry that will initiate fibrillation. If the shocks are made incrementally larger, a shock level will be reached that is high enough not to start fibrillation in regular rhythm regardless of when it is delivered during the cardiac cycle. This shock level is called the upper limit of vulnerability. In this study, the formation of reentrant circuits with defibrillation-sized shocks and how this formation of reentrant circuits may be related to mechanism of defibrillation, via the upper limit of vulnerability hypothesis are discussed. |
| | |
Authors:
|
G P Walcott; K T Walcott; R E Ideker |
Related Documents
:
|
3345865 - Ontogeny of conditioned heart rate to an olfactory stimulus. 8161395 - Imipramine-provoked paradoxical pheochromocytoma crisis: a case of cardiogenic shock. 19542875 - Arrhythmia and acute coronary syndrome suppression and cardiac resuscitation management... 15295725 - Efficacy of lower-energy biphasic shocks for transthoracic defibrillation: a follow-up ... 10803005 - Complications from cardiac catheterization: analysis of a military database. 4593555 - A randomized controlled trial of acetyl salicylic acid in the secondary prevention of m... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Journal of electrocardiology Volume: 28 Suppl ISSN: 0022-0736 ISO Abbreviation: J Electrocardiol Publication Date: 1995 |
Date Detail:
|
Created Date: 1996-07-26 Completed Date: 1996-07-26 Revised Date: 2009-11-11 |
Medline Journal Info:
|
Nlm Unique ID: 0153605 Medline TA: J Electrocardiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1-6 Citation Subset: IM |
Affiliation:
|
Department of Medicine, University of Alabama at Birmingham 35294-0019, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Action Potentials Animals Body Surface Potential Mapping Cardiac Pacing, Artificial Electric Countershock / methods* Heart Conduction System / physiopathology Heart Rate Heart Ventricles / physiopathology Humans Models, Neurological Refractory Period, Electrophysiological Ventricular Fibrillation / physiopathology, therapy* |
| Grant Support | |
ID/Acronym/Agency:
|
HL-42760/HL/NHLBI NIH HHS; HL-44066/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Outlook for clinical hemorheology
Next Document: Interpolation of body surface potential maps.