| Mechanisms of cutaneous vasodilation during the postmenopausal hot flash. | |
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MedLine Citation:
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PMID: 21107299 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Menopausal hot flashes can seriously disrupt the lives of symptomatic women. The physiological mechanisms of the hot flash efferent responses, particularly in the cutaneous circulation, are not completely understood. The aim of this study was to examine the mechanisms of increases in skin blood flow during the postmenopausal hot flash in symptomatic women. METHODS: Healthy postmenopausal women rested in a temperature-controlled laboratory while responses before and during hot flashes were recorded for three unique protocols. In protocols 1 and 2, women were locally pretreated with an intradermal injection of botulinum toxin A (BTX; blocks the release of neurotransmitters from sympathetic cholinergic nerves) in the forearm (protocol 1) and in the glabellar region (protocol 2). In protocol 3, skin sympathetic nerve activity from the peroneal nerve was recorded, along with skin blood flow and sweating within the region innervated by that neural signal. Skin blood flow was indexed using laser-Doppler flowmetry at the BTX-treated and adjacent untreated control sites. The onset of a hot flash was objectively identified as a transient and pronounced increase in sternal sweat rate. RESULTS: The increases in forearm (protocol 1) and glabellar skin (protocol 2) blood flow during hot flashes were attenuated at the BTX sites relative to the adjacent untreated sites (P<0.05 for both protocols). In protocol 3, skin sympathetic nerve activity significantly increased during hot flashes and returned to pre-hot flash levels after the hot flashes. CONCLUSIONS: Increases in skin blood flow during postmenopausal hot flashes are neurally mediated primarily through BTX-sensitive nerves, presumably sympathetic cholinergic. |
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Authors:
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David A Low; Kimberley A Hubing; Juan Del Coso; Craig G Crandall |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Menopause (New York, N.Y.) Volume: 18 ISSN: 1530-0374 ISO Abbreviation: Menopause Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-06-24 Completed Date: 2011-10-27 Revised Date: 2012-04-04 |
Medline Journal Info:
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Nlm Unique ID: 9433353 Medline TA: Menopause Country: United States |
Other Details:
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Languages: eng Pagination: 359-65 Citation Subset: IM |
Copyright Information:
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© 2011 by The North American Menopause Society |
Affiliation:
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From the 1Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital of Dallas, Dallas, TX 75231, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Botulinum Toxins, Type A
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administration & dosage Female Hot Flashes / physiopathology* Humans Injections, Intradermal Middle Aged Neurotoxins / administration & dosage Postmenopause* Regional Blood Flow / drug effects, physiology* Skin / blood supply* Sweating / drug effects, physiology Sympathetic Nervous System / drug effects, physiology* Vasodilation / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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AG030189/AG/NIA NIH HHS; R21 AG030189-01A1/AG/NIA NIH HHS; R21 AG030189-02/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Neurotoxins; EC 3.4.24.69/Botulinum Toxins, Type A |
| Comments/Corrections | |
Comment In:
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Menopause. 2011 Apr;18(4):348-9
[PMID:
21407134
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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