Document Detail

Mechanisms controlling sex myoblast migration in Caenorhabditis elegans hermaphrodites.
MedLine Citation:
PMID:  10993679     Owner:  NLM     Status:  MEDLINE    
Sex myoblast migration in C. elegans hermaphrodites is controlled by multiple guidance mechanisms. A gonad-dependent attraction functions to guide the sex myoblasts to their precise final positions flanking the gonad. In the absence of this attraction, a gonad-dependent repulsion is revealed. In addition to gonad-dependent influences, a gonad-independent mechanism propels the sex myoblasts anteriorly to a broad range of positions near the center of the animal. Here we describe a temporal analysis of sex myoblast migration that reveals when the gonad-dependent attraction and the gonad-independent mechanisms normally function. We provide evidence that EGL-17, a fibroblast growth factor-like protein, is expressed in the gonadal cells required to attract the sex myoblasts to their precise final positions, further supporting our model that EGL-17 defines the gonad-dependent attractant. Furthermore, cell ablation experiments reveal that EGL-17 and the gonad-dependent repellent likely emanate from the same cellular sources. Analyses of candidate mutations for their effects on the gonad-dependent repulsion reveal that a set of genes known to affect multiple aspects of axonogenesis, unc-14, unc-33, unc-44, and unc-51, is essential for this repulsive mechanism. In addition, we have discovered that a SAX-3/Roundabout-dependent mechanism is used to maintain the sex myoblasts along the ventral muscle quadrants.
C S Branda; M J Stern
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Developmental biology     Volume:  226     ISSN:  0012-1606     ISO Abbreviation:  Dev. Biol.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-11-03     Completed Date:  2000-11-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372762     Medline TA:  Dev Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  137-51     Citation Subset:  IM    
Copyright Information:
Copyright 2000 Academic Press.
Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06520-8005, USA.
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MeSH Terms
Caenorhabditis elegans / cytology*,  physiology
Caenorhabditis elegans Proteins*
Cell Movement / physiology*
Fibroblast Growth Factors / physiology
Gonads / cytology*
Growth Substances / physiology
Helminth Proteins / physiology
Intercellular Signaling Peptides and Proteins*
Nerve Tissue Proteins
Receptors, Immunologic / physiology
Reg. No./Substance:
0/Caenorhabditis elegans Proteins; 0/Egl-17 protein, C elegans; 0/Growth Substances; 0/Helminth Proteins; 0/Intercellular Signaling Peptides and Proteins; 0/Nerve Tissue Proteins; 0/Receptors, Immunologic; 0/roundabout protein; 62031-54-3/Fibroblast Growth Factors

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