| Mechanisms controlling cell cycle exit upon terminal differentiation. | |
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MedLine Citation:
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PMID: 18035529 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Coordinating terminal differentiation with permanent exit from the cell cycle is crucial for proper organogenesis, yet how the cell cycle is blocked in differentiated tissues remains unclear. Important roles for retinoblastoma family proteins and Cyclin-dependent kinase inhibitors have been delineated, but in many cases it remains unclear what triggers cell cycle exit. This review focuses on describing recent advances in deciphering how terminal differentiation and exit from the cell cycle are coordinated. |
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Authors:
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Laura A Buttitta; Bruce A Edgar |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2007-11-26 |
Journal Detail:
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Title: Current opinion in cell biology Volume: 19 ISSN: 0955-0674 ISO Abbreviation: Curr. Opin. Cell Biol. Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-12-11 Completed Date: 2008-02-05 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 8913428 Medline TA: Curr Opin Cell Biol Country: United States |
Other Details:
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Languages: eng Pagination: 697-704 Citation Subset: IM |
Affiliation:
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Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Cycle / physiology* Cell Differentiation / physiology* Gene Expression Regulation* Humans Signal Transduction* |
| Grant Support | |
ID/Acronym/Agency:
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GM070887/GM/NIGMS NIH HHS; R01 GM070887-03/GM/NIGMS NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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