Document Detail


Mechanisms for complexity in the brain: generating the insect central complex.
MedLine Citation:
PMID:  21397959     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The central complex of the insect brain is a remarkably miniaturized but highly complex multimodal information-processing network. Recent work on central complex development in Drosophila and grasshopper reveals that the cells comprising its complex circuitry are generated by a surprisingly small number of primary progenitors. Of these, four identified neural stem cells generate a large number of neurons through a novel mode of neurogenesis that involves self-renewing intermediate progenitor cells. Interestingly, a comparable mode of amplification of proliferation also operates in the developing mammalian cortex; this could be a general strategy for increasing brain size and complexity. Although this type of proliferation generates a large number of progeny, it is also prone to dysregulation, resulting in brain tumors. Thus, furthering our knowledge of the development of the central complex is likely to be valuable not only for understanding brain complexity but could also have important implications for identifying developmental pathways that go awry during tumor formation.
Authors:
George S Boyan; Heinrich Reichert
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-11
Journal Detail:
Title:  Trends in neurosciences     Volume:  -     ISSN:  1878-108X     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7808616     Medline TA:  Trends Neurosci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier Ltd.
Affiliation:
Biocenter, University of Munich, Grosshadernerstrasse 2, 82152 Martinsried, Germany.
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