Document Detail

Mechanisms of chronic heart failure development in end-stage renal disease patients on chronic hemodialysis.
MedLine Citation:
PMID:  19093713     Owner:  NLM     Status:  In-Process    
More than 50 % of end-stage renal disease (ESRD) patients treated by chronic hemodialysis die from cardiovascular diseases, including congestive heart failure (CHF). The incidence of CHF is rising in both general and ESRD population. However, the mechanisms, which lead to the development of CHF in dialyzed patients, differ considerably. First, there are several factors leading to increase of the left ventricular afterload: volume overload between dialyses, hypertension, increased arterial stiffness, anemia, vascular access flow (arteriovenous fistula) and sympathetic activation. Second, hypertension, left ventricular hypertrophy, anemia and frequently present coronary artery disease worsen myocardial oxygenation. The combination of these factors explains the high incidence of CHF in dialyzed patients and their roles are reviewed in this article.
J Mal??k; V Tuka; M Mokrejsov??; R Holaj; V Tesar
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-11-04
Journal Detail:
Title:  Physiological research / Academia Scientiarum Bohemoslovaca     Volume:  58     ISSN:  0862-8408     ISO Abbreviation:  Physiol Res     Publication Date:  2009  
Date Detail:
Created Date:  2009-12-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9112413     Medline TA:  Physiol Res     Country:  Czech Republic    
Other Details:
Languages:  eng     Pagination:  613-21     Citation Subset:  IM    
Third Department of Internal Medicine, General University Hospital, U nemocnice 1, 128 08 Prague, Czech Republic.
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