| Mechanisms of changes to the liver pigmentary component during the annual cycle (activity and hibernation) of Rana esculenta L. | |
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MedLine Citation:
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PMID: 11895116 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study was performed to elucidate the mechanisms responsible for the changes of melanin content/ distribution we had previously discovered in the liver parenchyma of Rana esculenta during natural hibernation. Melanomacrophagic component response was analysed using morphocytochemical methods. The results demonstrated that during the prehibernation period (October-November) the melanomacrophages reach the highest proliferative activity (BrdU, PCNA labelling) which is accompanied by an evident melanosynthesis (dopa-oxidase activity). In contrast, after hibernation, the decrease of liver pigmentation was the consequence of a partial cell loss by apoptotic mechanisms (TUNEL labelling, pyknosis-karyorhexis) accompanied by a decrease of melanosome content by autophagy and low melanosynthetic activity. On the basis of these findings, there is evidence that liver melanomacrophages represent a metabolically (melanin synthesis/degradation) and cytokinetically (proliferation/ death) active cell population during the annual cycle of the frog. The results are also discussed in relation to the functional synergism between hepatocytes and pigment cells in the adaptation to environmental changes. |
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Authors:
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Sergio Barni; Rita Vaccarone; Vittorio Bertone; Annunzia Fraschini; Franco Bernini; Carla Fenoglio |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of anatomy Volume: 200 ISSN: 0021-8782 ISO Abbreviation: J. Anat. Publication Date: 2002 Feb |
Date Detail:
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Created Date: 2002-03-15 Completed Date: 2002-03-25 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0137162 Medline TA: J Anat Country: England |
Other Details:
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Languages: eng Pagination: 185-94 Citation Subset: IM |
Affiliation:
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Department of Animal Biology and CNR Center for Histochemistry, University of Pavia, Italy. barni@unipv.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Apoptosis / physiology Cell Count Cell Division / physiology Hibernation / physiology* Immunohistochemistry / methods Liver / chemistry, cytology, metabolism* Macrophages / chemistry, metabolism* Male Melanins / analysis, metabolism* Rana esculenta / anatomy & histology* |
| Chemical | |
Reg. No./Substance:
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0/Melanins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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