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Mechanisms of cellular uptake of cell-penetrating peptides.
MedLine Citation:
PMID:  21687343     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Recently, much attention has been given to the problem of drug delivery through the cell-membrane in order to treat and manage several diseases. The discovery of cell penetrating peptides (CPPs) represents a major breakthrough for the transport of large-cargo molecules that may be useful in clinical applications. CPPs are rich in basic amino acids such as arginine and lysine and are able to translocate over membranes and gain access to the cell interior. They can deliver large-cargo molecules, such as oligonucleotides, into cells. Endocytosis and direct penetration have been suggested as the two major uptake mechanisms, a subject still under debate. Unresolved questions include the detailed molecular uptake mechanism(s), reasons for cell toxicity, and the delivery efficiency of CPPs for different cargoes. Here, we give a review focused on uptake mechanisms used by CPPs for membrane translocation and certain experimental factors that affect the mechanism(s).
Authors:
Fatemeh Madani; Staffan Lindberg; Ulo Langel; Shiroh Futaki; Astrid Gräslund
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Publication Detail:
Type:  Journal Article     Date:  2011-04-07
Journal Detail:
Title:  Journal of biophysics (Hindawi Publishing Corporation : Online)     Volume:  2011     ISSN:  1687-8019     ISO Abbreviation:  J Biophys     Publication Date:  2011  
Date Detail:
Created Date:  2011-06-20     Completed Date:  2011-07-14     Revised Date:  2011-08-01    
Medline Journal Info:
Nlm Unique ID:  101519205     Medline TA:  J Biophys     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  414729     Citation Subset:  -    
Affiliation:
Department of Biochemistry and Biophysics, Arrhenius Laboratories for Natural Sciences, Stockholm University, 10691 Stockholm, Sweden.
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