Document Detail


Mechanisms and cellular roles of local protein synthesis in mammalian cells.
MedLine Citation:
PMID:  18378131     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
After the export from the nucleus it turns out that all mRNAs are not treated equally. Not only is mRNA subject to translation, but also through RNA-binding proteins and other trans-acting factors, eukaryotic cells interpret codes for spatial sorting within the mRNA sequence. These codes instruct the cytoskeleton and translation apparatus to make decisions about where to transport and when to translate the intended protein product. Signaling pathways decode extra-cellular cues and can modify transport and translation factors in the appropriate cytoplasmic space to achieve translation locally. Identifying regulatory sites on transport factors as well as novel physiological functions for well-known translation factors has provided significant advances in how spatially controlled translation impacts cell function.
Authors:
Alexis J Rodriguez; Kevin Czaplinski; John S Condeelis; Robert H Singer
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2008-04-02
Journal Detail:
Title:  Current opinion in cell biology     Volume:  20     ISSN:  0955-0674     ISO Abbreviation:  Curr. Opin. Cell Biol.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-14     Completed Date:  2008-07-07     Revised Date:  2014-09-16    
Medline Journal Info:
Nlm Unique ID:  8913428     Medline TA:  Curr Opin Cell Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  144-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Adhesion
Cells / cytology*,  metabolism*
Humans
Protein Biosynthesis*
RNA, Messenger / genetics,  metabolism
RNA-Binding Proteins / metabolism
Synapses / metabolism
Grant Support
ID/Acronym/Agency:
AR41480/AR/NIAMS NIH HHS; CA100324/CA/NCI NIH HHS; R01 AR041480/AR/NIAMS NIH HHS; R01 AR041480-14/AR/NIAMS NIH HHS; R01 EB002060/EB/NIBIB NIH HHS; R01 EB002060-24/EB/NIBIB NIH HHS; R01 GM057071/GM/NIGMS NIH HHS; R01 GM057071-10/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/RNA, Messenger; 0/RNA-Binding Proteins
Comments/Corrections

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