Document Detail


Mechanisms of cell volume regulation and possible nature of the cell volume sensor.
MedLine Citation:
PMID:  11720802     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In animal organisms, cell volume undergoes dynamic changes in many physiological and pathological processes. To protect themselves against lysis and apoptosis and to maintain an optimal concentration of intracellular enzymes and metabolites, most animal cells actively regulate their volume. In the present review, we shortly summarize the data on ion transport mechanisms involved in regulatory volume decrease (RVD) and regulatory volume increase (RVI) with an emphasis on unresolved aspects of this problem such as: (i) how cells sense their volume changes; (ii) what signals are generated upon cell volume alterations; and (iii) how these signals are transferred to the ion transport systems executing cell volume regulation.
Authors:
Alexander A. Mongin; Sergei N. Orlov
Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Pathophysiology : the official journal of the International Society for Pathophysiology / ISP     Volume:  8     ISSN:  -     ISO Abbreviation:  Pathophysiology     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2001-Nov-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9433813     Medline TA:  Pathophysiology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  77-88     Citation Subset:  -    
Affiliation:
Albany Medical College, 12208, Albany, NY, USA
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