Document Detail

Mechanisms of cell killing/cytopathic effects by nonhuman retroviruses.
MedLine Citation:
PMID:  2836939     Owner:  NLM     Status:  MEDLINE    
Retroviruses have been studied primarily for their role in cancer. However, with the AIDS epidemic, attention has shifted to the other effects of retroviral infection. In particular, since human immunodeficiency virus results in killing of CD4-positive T cells, there is interest in the mechanism of cell killing by retroviruses. Numerous other retroviruses are also cytopathic. Studies of these other retroviruses are reviewed in this article. In particular, the hypothesis that cell killing is the result of superinfection or other increased viral envelope protein-cell receptor interaction is suggested.
H M Temin
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Reviews of infectious diseases     Volume:  10     ISSN:  0162-0886     ISO Abbreviation:  Rev. Infect. Dis.     Publication Date:    1988 Mar-Apr
Date Detail:
Created Date:  1988-06-29     Completed Date:  1988-06-29     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7905878     Medline TA:  Rev Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  399-405     Citation Subset:  IM; X    
McArdle Laboratory, University of Wisconsin, Madison 53706.
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MeSH Terms
Cell Survival
Cells, Cultured
Cytopathogenic Effect, Viral
Retroviridae / physiology*
Retroviridae Infections / microbiology*

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