| Mechanisms of carotid chemoreceptor resetting after birth. In vitro studies. | |
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MedLine Citation:
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PMID: 9030279 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The results of these studies are consistent with the hypothesis that carotid chemoreceptor type-I cell resetting occurs, at least in part, at the level of the type-I cell. Furthermore, we have developed an in vitro model of newborn type-I cell resetting, in which freshly isolated glomus cells from newborns exhibit small, immature [Ca2+]i response to anoxia, but-after 72 hours in culture-[Ca2+]i responses convert to adult magnitude and profile. Finally, work so far suggests that glomus cell resetting in this model is modulated by oxygen tension. The mechanisms of glomus cell resetting remain unknown. Resetting of O2 sensitivity could result from withdrawal of tonic inhibitory influences present in vivo, changes in the oxygen sensor itself, changes in ion channel expression, modulation, and function, or other mechanisms occurring around the time of birth. Additional work is needed to determine the mechanisms of glomus cell resetting at the cellular level, and the role of O2 tension and other potential modulators of resetting. |
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Authors:
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J L Carroll; L M Sterni; O S Bamford; M H Montrose |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Advances in experimental medicine and biology Volume: 410 ISSN: 0065-2598 ISO Abbreviation: Adv. Exp. Med. Biol. Publication Date: 1996 |
Date Detail:
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Created Date: 1997-06-05 Completed Date: 1997-06-05 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 0121103 Medline TA: Adv Exp Med Biol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 73-7 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Johns Hopkins Children's Center, Baltimore, Maryland, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn / physiology* Anoxia / physiopathology Calcium / physiology Carotid Body / cytology, growth & development*, physiology Carotid Sinus / innervation Cats Cell Hypoxia / physiology Cells, Cultured Humans Infant, Newborn / physiology* Models, Biological Oxygen / blood* Rabbits Rats Respiration / physiology Sheep / growth & development Species Specificity Swine / growth & development |
| Chemical | |
Reg. No./Substance:
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7440-70-2/Calcium; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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