Document Detail


Mechanisms of cardioprotection by isoflurane against I/R injury.
MedLine Citation:
PMID:  23276931     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Myocardial infarction is responsible for most cardiovascular mortality as well as the pathogenesis of myocardial damage during and after infarction. Efforts are underway to modulate the development of ischemia-reperfusion (I-R) injury. Recently, the protective effect of isoflurane against myocardial I-R injury emerged as a possibility. Nitric oxide, nitric oxide synthases, factors related to energy metabolism, adenosine triphosphate-sensitive potassium channels, phosphatidylinositol-3-kinase and hypoxia-inducible factor1-alpha have been shown to participate in the mechanisms of cardioprotection elicited by isoflurane against I-R injury. In this review, we focus on the mechanisms of cardioprotection offered by isoflurane against I-R injury.
Authors:
Xiao-E Lang; Xiong Wang; Jian-Hua Jin
Publication Detail:
Type:  Journal Article; Review     Date:  2013-01-01
Journal Detail:
Title:  Frontiers in bioscience (Landmark edition)     Volume:  18     ISSN:  1093-4715     ISO Abbreviation:  Front Biosci (Landmark Ed)     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  2013-06-12     Revised Date:  2013-07-29    
Medline Journal Info:
Nlm Unique ID:  101612996     Medline TA:  Front Biosci (Landmark Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  387-93     Citation Subset:  IM    
Affiliation:
Department of Cardiology, First Hospital, Shanxi Medical University, Taiyuan Shanxi,030001, P. R. China. xiaoelang@yeah.net
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MeSH Terms
Descriptor/Qualifier:
Humans
Hypoxia-Inducible Factor 1, alpha Subunit / physiology
Isoflurane / therapeutic use*
KATP Channels / physiology
Myocardial Reperfusion Injury / prevention & control*
Nitric Oxide Synthase Type II / metabolism
Nitric Oxide Synthase Type III / metabolism
Potassium Channels / metabolism
Protein Kinase C / metabolism
Receptor, Adenosine A1 / physiology
Chemical
Reg. No./Substance:
0/HIF1A protein, human; 0/Hypoxia-Inducible Factor 1, alpha Subunit; 0/KATP Channels; 0/Potassium Channels; 0/Receptor, Adenosine A1; 26675-46-7/Isoflurane; EC 1.14.13.39/NOS2 protein, human; EC 1.14.13.39/NOS3 protein, human; EC 1.14.13.39/Nitric Oxide Synthase Type II; EC 1.14.13.39/Nitric Oxide Synthase Type III; EC 2.7.11.13/Protein Kinase C

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