| Mechanisms of cardiac nerve sprouting after myocardial infarction in dogs. | |
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MedLine Citation:
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PMID: 15166093 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cardiac nerve sprouting and sympathetic hyperinnervation after myocardial infarction (MI) both contribute to arrhythmogenesis and sudden death. However, the mechanisms responsible for nerve sprouting after MI are unclear. The expression of nerve growth factor (NGF), growth associated protein 43 (GAP43), and other nerve markers were studied at the infarcted site, the noninfarcted left ventricle free wall (LVFW), and the left stellate ganglion (LSG) at several time points (30 minutes to 1 month) after MI. Transcardiac (difference between coronary sinus and aorta) NGF levels were also assayed. Acute MI resulted in the immediate elevation of the transcardiac NGF concentration within 3.5 hours after MI, followed by the upregulation of cardiac NGF and GAP43 expression, which was earlier and more pronounced at the infarcted site than the noninfarcted LVFW. However, cardiac nerve sprouting and sympathetic hyperinnervation were more pronounced in the noninfarcted than the infarcted LVFW site and peaked at 1 week after MI. The NGF and GAP43 protein levels significantly increased in the LSG from 3 days (P<0.01 for all) after MI, without a concomitant increase in mRNA. There was persistent elevation of NGF levels in aorta and coronary sinus within 1 month after MI. We conclude MI results in immediate local NGF release, followed by upregulation of NGF and GAP43 expression at the infarcted site. NGF and GAP43 are transported retrogradely to LSG, which triggers nerve sprouting at the noninfarcted LVFW. A rapid and persistent upregulation of NGF and GAP43 expression at the infarcted site underlies the mechanisms of cardiac nerve sprouting after MI. |
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Authors:
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Shengmei Zhou; Lan S Chen; Yasushi Miyauchi; Mizuho Miyauchi; Saibal Kar; Simon Kangavari; Michael C Fishbein; Behrooz Sharifi; Peng-Sheng Chen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. Date: 2004-05-27 |
Journal Detail:
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Title: Circulation research Volume: 95 ISSN: 1524-4571 ISO Abbreviation: Circ. Res. Publication Date: 2004 Jul |
Date Detail:
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Created Date: 2004-07-09 Completed Date: 2004-11-30 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0047103 Medline TA: Circ Res Country: United States |
Other Details:
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Languages: eng Pagination: 76-83 Citation Subset: IM |
Affiliation:
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Division of Cardiology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dogs GAP-43 Protein / metabolism Gene Expression Heart / innervation* Kinetics Myocardial Infarction / genetics, metabolism, physiopathology* Nerve Growth Factor / metabolism Nerve Regeneration* Nerve Tissue Proteins / biosynthesis, genetics Stellate Ganglion / metabolism Sympathetic Nervous System / cytology, physiology |
| Grant Support | |
ID/Acronym/Agency:
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HL66389/HL/NHLBI NIH HHS; HL71140/HL/NHLBI NIH HHS; P50 HL52319/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/GAP-43 Protein; 0/Nerve Tissue Proteins; 9061-61-4/Nerve Growth Factor |
| Comments/Corrections | |
Comment In:
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Circ Res. 2004 Jul 9;95(1):5-6
[PMID:
15242979
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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