Document Detail


Mechanisms for cardiac arrhythmias.
MedLine Citation:
PMID:  3311793     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Possible cellular electrophysiological mechanisms for arrhythmias have been investigated through studies of isolated cardiac tissues. Records through extracellular and intracellular electrodes indicate that arrhythmias may result from either focal or non-focal mechanisms. Focal mechanisms include abnormal impulse initiation (normal or abnormal automaticity), triggering from either early or delayed afterdepolarizations and reflection, whereas the non-focal mechanisms are various forms of reentry due to circus movement. It is reasonable to assume that these mechanisms also occur in vivo. Although it is safe to identify macro-re-entry as the cause of some atrial and ventricular arrhythmias, for the most part direct proof of mechanism usually is lacking for the focal arrhythmias. If 'on line' activation sequence mapping techniques can be developed to quickly and specifically locate arrhythmogenic foci in the in situ heart, it may be possible to use unipolar extracellular recording techniques to identify the exact cellular electrophysiological mechanisms operating within them.
Authors:
B F Hoffman; K H Dangman
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Experientia     Volume:  43     ISSN:  0014-4754     ISO Abbreviation:  Experientia     Publication Date:  1987 Oct 
Date Detail:
Created Date:  1987-11-30     Completed Date:  1987-11-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376547     Medline TA:  Experientia     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  1049-56     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Columbia University, New York, New York 10032.
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MeSH Terms
Descriptor/Qualifier:
Action Potentials
Animals
Arrhythmias, Cardiac / etiology*,  physiopathology
Electrophysiology
Heart / physiopathology*
Heart Atria / physiopathology
Heart Conduction System / physiopathology
Heart Ventricles / physiopathology
Membrane Potentials
Purkinje Fibers / physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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