Document Detail

Mechanisms of calcium's effects on blood pressure.
MedLine Citation:
PMID:  8588118     Owner:  NLM     Status:  MEDLINE    
Manipulations of dietary calcium have been repeatedly shown to alter blood pressure in animal models of human essential hypertension. Supplemental dietary calcium lowers blood pressure, whereas restricted calcium diets tend to elevate blood pressure. The mechanisms responsible have not been identified, but numerous possibilities have been proposed. Many of the proposals have attempted to relate dietary calcium to calcium metabolism in vascular smooth muscle and altered vascular tone. Other proposals have focused on neural, hormonal, and renal effects of dietary calcium. In this article, mechanisms through which elevations in extracellular calcium levels might influence intracellular calcium levels are explored. Also examined are the potential roles of calcium regulating hormones, sympathetic nervous system, and electrolyte interactions in modifying blood pressure.
D C Hatton; Q Yue; D A McCarron
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in nephrology     Volume:  15     ISSN:  0270-9295     ISO Abbreviation:  Semin. Nephrol.     Publication Date:  1995 Nov 
Date Detail:
Created Date:  1996-03-28     Completed Date:  1996-03-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8110298     Medline TA:  Semin Nephrol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  593-602     Citation Subset:  IM; S    
Division of Nephrology, Hypertension, and Clinical Pharmacology, Oregon Health Sciences University, Portland 97201, USA.
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MeSH Terms
Blood Pressure / drug effects,  physiology
Calcium / metabolism*
Calcium, Dietary / metabolism*,  therapeutic use
Hypertension* / diet therapy,  physiopathology
Muscle, Smooth, Vascular / drug effects*
Rats, Inbred SHR
Reg. No./Substance:
0/Calcium, Dietary; 7440-70-2/Calcium

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