| Mechanisms of calcium transient and action potential alternans in cardiac cells and tissues. | |
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MedLine Citation:
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PMID: 17951365 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Alternation of cardiac action potential duration (APD) from beat to beat and concurrent alternation of the amplitude of the calcium transient are regarded as important arrhythmia mechanisms. These phenomena are causally interrelated and can be reliably evoked by an increase in beat frequency or by ischemia. The first part of this historical review deals with the physiology of APD alternans. Sections recounting the evolution of knowledge about calcium-activated ion currents and calcium transient alternans are interspersed among sections describing the growth of the so-called "restitution hypothesis," which involves time-dependent recovery of potassium channels (including their passage through pre-open states) as a function of diastolic interval. Major developments are generally in chronological order, but it is necessary to move back and forth between the two theories to respect the overall time line, which runs from about l965 to the present. The concluding two sections deal with the pathophysiology of calcium transient and APD alternans during ischemia, which may be the basis for out-of-hospital cardiac arrest during the initial stages of acute myocardial infarction. |
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Authors:
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William T Clusin |
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Publication Detail:
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Type: Historical Article; Journal Article; Review Date: 2007-10-19 |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: 294 ISSN: 0363-6135 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2008-01-14 Completed Date: 2008-02-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
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Languages: eng Pagination: H1-H10 Citation Subset: IM |
Affiliation:
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Stanford University School of Medicine, Stanford, CA 94305, USA. wclusin@stanford.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials* Animals Arrhythmias, Cardiac / complications, etiology*, metabolism, physiopathology Calcium Signaling* Cardiac Electrophysiology* / history Cardiopulmonary Resuscitation Death, Sudden, Cardiac / etiology, prevention & control History, 20th Century History, 21st Century Humans Models, Cardiovascular Myocardial Ischemia / complications, metabolism*, physiopathology Myocardium / metabolism* Potassium / metabolism Potassium Channels, Calcium-Activated / metabolism Sodium / metabolism Sodium Channels / metabolism Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Potassium Channels, Calcium-Activated; 0/Sodium Channels; 7440-09-7/Potassium; 7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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