Document Detail


Mechanisms by which mammalian cells acquire resistance to drugs that affect microtubule assembly.
MedLine Citation:
PMID:  2646163     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The development of resistance in mammalian cells to toxic drugs is a significant clinical problem, especially in cancer chemotherapy where drug-resistant tumor cells often prove to be refractory to treatment. In this article, we review some of the basic mechanisms of drug resistance from the perspective of a single cell bathed in medium containing the drug. These mechanisms may be categorized according to changes in the cell that affect the ability of the drug to accumulate intracellularly, changes in enzymes that are required for drug toxicity, alterations in trapping of the drug or detoxification of the drug, alterations in binding to an intracellular target, or alterations in cellular processes that compensate for the action of the drug. This latter mechanism is illustrated in some depth by discussing mutants of Chinese hamster ovary cells that are resistant to the effects of drugs that interfere with microtubule assembly.
Authors:
F Cabral; S B Barlow
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  FASEB journal : official publication of the Federation of American Societies for Experimental Biology     Volume:  3     ISSN:  0892-6638     ISO Abbreviation:  FASEB J.     Publication Date:  1989 Mar 
Date Detail:
Created Date:  1989-04-14     Completed Date:  1989-04-14     Revised Date:  2012-02-15    
Medline Journal Info:
Nlm Unique ID:  8804484     Medline TA:  FASEB J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1593-9     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, University of Texas Medical School, Houston 77225.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antifungal Agents / pharmacology
Antineoplastic Agents / pharmacology
Cell Line
Drug Resistance*
Herbicides / pharmacology
Microtubules / drug effects*,  metabolism
Mutation
Tubulin / metabolism
Grant Support
ID/Acronym/Agency:
GM 29955/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Antifungal Agents; 0/Antineoplastic Agents; 0/Herbicides; 0/Tubulin

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