Document Detail

Mechanisms of bone remodeling during weight-bearing exercise.
MedLine Citation:
PMID:  17213879     Owner:  NLM     Status:  MEDLINE    
Exercise-induced mechanical loading can have potent effects on skeletal form and health. Both intrinsic and extrinsic factors contribute to bone structure and function. Mechanical simuli (e.g., strain magnitude, frequency, rate, and gradients, as well as fluid flow and shear stress) have potent influences on bone-cell cytoskeleton and associated signalling pathways. Although the immature skeleton may be more able to benefit from exercise, a skeletally mature population can also benefit from exercise programs aimed at increasing the functional loads to which the skeleton is exposed. The definitive explanation of mechanical-loading and (or) bone-cell mechanotransductive phenomena, however, remains elusive. Here, we briefly review the structural and anatomical foundation for bone adaptation, focusing on mechanical loading effects on bone, linked to the roles of integrins, cytoskeleton, membrane channels, and auto- and paracrine factors in bone modeling and remodeling.
Ronald Zernicke; Christopher MacKay; Caeley Lorincz
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Applied physiology, nutrition, and metabolism = Physiologie appliquée, nutrition et métabolisme     Volume:  31     ISSN:  1715-5312     ISO Abbreviation:  -     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2007-01-10     Completed Date:  2007-06-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101264333     Medline TA:  Appl Physiol Nutr Metab     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  655-60     Citation Subset:  IM    
Faculty of Kinesiology, University of Calgary, 2500 University Drive NW, Calgary, AB T2N 1N4, Canada.
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MeSH Terms
Autocrine Communication / physiology
Bone Remodeling / physiology*
Cytoskeleton / physiology
Exercise / physiology*
Paracrine Communication / physiology
Weight-Bearing / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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